ENSG00000057252


Homo sapiens

Features
Gene ID: ENSG00000057252
  
Biological name :SOAT1
  
Synonyms : P35610 / SOAT1 / sterol O-acyltransferase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q25.2
Gene start: 179293714
Gene end: 179358680
  
Corresponding Affymetrix probe sets: 221561_at (Human Genome U133 Plus 2.0 Array)   228479_at (Human Genome U133 Plus 2.0 Array)   244661_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445315
Ensembl peptide - ENSP00000356591
Ensembl peptide - ENSP00000411309
Ensembl peptide - ENSP00000441356
NCBI entrez gene - 6646     See in Manteia.
OMIM - 102642
RefSeq - XM_011509912
RefSeq - NM_001252511
RefSeq - NM_001252512
RefSeq - NM_003101
RefSeq - XM_011509911
RefSeq Peptide - NP_001239441
RefSeq Peptide - NP_003092
RefSeq Peptide - NP_001239440
swissprot - P35610
swissprot - B1APM4
Ensembl - ENSG00000057252
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 soat1ENSDARG00000062297Danio rerio
 SOAT1ENSGALG00000004205Gallus gallus
 Soat1ENSMUSG00000026600Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOAT2 / O75908 / sterol O-acyltransferase 2ENSG0000016778044
DGAT1 / O75907 / diacylglycerol O-acyltransferase 1ENSG0000018500018


Protein motifs (from Interpro)
Interpro ID Name
 IPR004299  Membrane bound O-acyl transferase, MBOAT
 IPR014371  Sterol O-acyltransferase, ACAT/DAG/ARE types
 IPR030687  Sterol O-acyltransferase, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IMP
 biological_processGO:0010742 macrophage derived foam cell differentiation NAS
 biological_processGO:0010878 cholesterol storage IMP
 biological_processGO:0033344 cholesterol efflux IMP
 biological_processGO:0034379 very-low-density lipoprotein particle assembly IMP
 biological_processGO:0034383 low-density lipoprotein particle clearance TAS
 biological_processGO:0034435 cholesterol esterification IMP
 biological_processGO:0042632 cholesterol homeostasis TAS
 biological_processGO:0042986 positive regulation of amyloid precursor protein biosynthetic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000062 fatty-acyl-CoA binding IDA
 molecular_functionGO:0004772 sterol O-acyltransferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008374 O-acyltransferase activity IEA
 molecular_functionGO:0015485 cholesterol binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0034736 cholesterol O-acyltransferase activity TAS


Pathways (from Reactome)
Pathway description
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr