ENSMUSG00000026600


Mus musculus

Features
Gene ID: ENSMUSG00000026600
  
Biological name :Soat1
  
Synonyms : Q61263 / Soat1 / Sterol O-acyltransferase 1
  
Possible biological names infered from orthology : P35610
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G3
Gene start: 156424525
Gene end: 156474331
  
Corresponding Affymetrix probe sets: 10359161 (MoGene1.0st)   1417695_a_at (Mouse Genome 430 2.0 Array)   1417696_at (Mouse Genome 430 2.0 Array)   1417697_at (Mouse Genome 430 2.0 Array)   1434362_at (Mouse Genome 430 2.0 Array)   1448068_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139431
Ensembl peptide - ENSMUSP00000141074
Ensembl peptide - ENSMUSP00000140721
Ensembl peptide - ENSMUSP00000058344
NCBI entrez gene - 20652     See in Manteia.
MGI - MGI:104665
RefSeq - XM_006496719
RefSeq - XM_011238778
RefSeq - NM_009230
RefSeq Peptide - NP_033256
swissprot - Q61263
swissprot - A0A087WSJ5
swissprot - A0A087WNN8
Ensembl - ENSMUSG00000026600
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 soat1ENSDARG00000062297Danio rerio
 SOAT1ENSGALG00000004205Gallus gallus
 SOAT1ENSG00000057252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Soat2 / O88908 / Sterol O-acyltransferase 2 / O75908*ENSMUSG0000002304544
Dgat1 / Q9Z2A7 / Diacylglycerol O-acyltransferase 1 / O75907*ENSMUSG0000002255519


Protein motifs (from Interpro)
Interpro ID Name
 IPR004299  Membrane bound O-acyl transferase, MBOAT
 IPR014371  Sterol O-acyltransferase, ACAT/DAG/ARE types
 IPR030687  Sterol O-acyltransferase, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process ISO
 biological_processGO:0010742 macrophage derived foam cell differentiation ISO
 biological_processGO:0010878 cholesterol storage ISO
 biological_processGO:0033344 cholesterol efflux ISO
 biological_processGO:0034379 very-low-density lipoprotein particle assembly ISO
 biological_processGO:0034435 cholesterol esterification ISO
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0042986 positive regulation of amyloid precursor protein biosynthetic process ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000062 fatty-acyl-CoA binding ISO
 molecular_functionGO:0004772 sterol O-acyltransferase activity ISO
 molecular_functionGO:0008374 O-acyltransferase activity IEA
 molecular_functionGO:0015485 cholesterol binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0034736 cholesterol O-acyltransferase activity ISO


Pathways (from Reactome)
Pathway description
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
Show

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001200 thick skin "greater depth of skin " [J:47225]
Show

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
Show

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
Show

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001337 dry eyes "absence of natural or normal moisture in the eye" [J:53284]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001345 meibomian gland atrophy "wasting of the sebaceous glands embedded in the tarsal plate of each eyelid resulting in reduced size" [J:65146]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Ntsr1tm2Dgen/Ntsr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Ntsr1tm2Dgen/Ntsr1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

 MP:0003692 xanthoma "a deposit of cholesterol rich material in a tissue, most often in the skin but also seen in tendons and in the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0003812 abnormal hair medulla "anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0003947 abnormal cholesterol level "anomaly in the concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Soat1tm1Ishi/Soat1tm1Ishi,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
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Allelic Composition: Slc12a2tm1Ges/Slc12a2tm1Ges
Genetic Background: Not Specified

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0008288 abnormal adrenal cortex morphology "any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008291 abnormal adrenocortical cell morphology "any structural anomaly of the steroid hormone-producing cells of the cortex of the adrenal gland" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat1tm1Far/Soat1tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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