ENSMUSG00000023045


Mus musculus

Features
Gene ID: ENSMUSG00000023045
  
Biological name :Soat2
  
Synonyms : O88908 / Soat2 / Sterol O-acyltransferase 2
  
Possible biological names infered from orthology : O75908
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F2
Gene start: 102150526
Gene end: 102163469
  
Corresponding Affymetrix probe sets: 10427131 (MoGene1.0st)   1460722_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023806
Ensembl peptide - ENSMUSP00000124628
NCBI entrez gene - 223920     See in Manteia.
MGI - MGI:1332226
RefSeq - NM_146064
RefSeq - XM_006520887
RefSeq Peptide - NP_666176
swissprot - F6SMH4
swissprot - O88908
Ensembl - ENSMUSG00000023045
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 soat2ENSDARG00000059824Danio rerio
 SOAT2ENSG00000167780Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Soat1 / Q61263 / Sterol O-acyltransferase 1 / P35610*ENSMUSG0000002660045
Dgat1 / Q9Z2A7 / Diacylglycerol O-acyltransferase 1 / O75907*ENSMUSG0000002255519


Protein motifs (from Interpro)
Interpro ID Name
 IPR004299  Membrane bound O-acyl transferase, MBOAT
 IPR014371  Sterol O-acyltransferase, ACAT/DAG/ARE types
 IPR030687  Sterol O-acyltransferase, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process ISO
 biological_processGO:0033344 cholesterol efflux IEA
 biological_processGO:0034379 very-low-density lipoprotein particle assembly IEA
 biological_processGO:0034435 cholesterol esterification ISO
 biological_processGO:0042632 cholesterol homeostasis IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000062 fatty-acyl-CoA binding IEA
 molecular_functionGO:0004772 sterol O-acyltransferase activity IDA
 molecular_functionGO:0008374 O-acyltransferase activity IEA
 molecular_functionGO:0015485 cholesterol binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0034736 cholesterol O-acyltransferase activity ISO


Pathways (from Reactome)
Pathway description
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0002647 decreased cholesterol absorption "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0005085 abnormal gall bladder physiology "anomalous action or function of the organ that stores and concentrates bile " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA

Allelic Composition: Soat2tm1.1Llr/Soat2tm1.1Llr,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

 MP:0011599 increased phosphatidylcholine-sterol O-acyltransferase activity "greater ability to catalyze the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine" [GO:0004731]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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