ENSG00000167780


Homo sapiens

Features
Gene ID: ENSG00000167780
  
Biological name :SOAT2
  
Synonyms : O75908 / SOAT2 / sterol O-acyltransferase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 53103518
Gene end: 53124538
  
Corresponding Affymetrix probe sets: 210677_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000301466
Ensembl peptide - ENSP00000442234
Ensembl peptide - ENSP00000450120
NCBI entrez gene - 8435     See in Manteia.
OMIM - 601311
RefSeq - XM_011538850
RefSeq - NM_003578
RefSeq - XM_011538849
RefSeq Peptide - NP_003569
swissprot - O75908
swissprot - F8VPE9
Ensembl - ENSG00000167780
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 soat2ENSDARG00000059824Danio rerio
 Soat2ENSMUSG00000023045Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOAT1 / P35610 / sterol O-acyltransferase 1ENSG0000005725246
DGAT1 / O75907 / diacylglycerol O-acyltransferase 1ENSG0000018500019


Protein motifs (from Interpro)
Interpro ID Name
 IPR004299  Membrane bound O-acyl transferase, MBOAT
 IPR014371  Sterol O-acyltransferase, ACAT/DAG/ARE types
 IPR030687  Sterol O-acyltransferase, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IDA
 biological_processGO:0010742 macrophage derived foam cell differentiation TAS
 biological_processGO:0030299 intestinal cholesterol absorption IC
 biological_processGO:0033344 cholesterol efflux IMP
 biological_processGO:0034379 very-low-density lipoprotein particle assembly IMP
 biological_processGO:0034383 low-density lipoprotein particle clearance TAS
 biological_processGO:0034435 cholesterol esterification IDA
 biological_processGO:0042632 cholesterol homeostasis IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000062 fatty-acyl-CoA binding IDA
 molecular_functionGO:0004772 sterol O-acyltransferase activity IEA
 molecular_functionGO:0008374 O-acyltransferase activity IEA
 molecular_functionGO:0015485 cholesterol binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups TAS
 molecular_functionGO:0034736 cholesterol O-acyltransferase activity TAS


Pathways (from Reactome)
Pathway description
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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