ENSMUSG00000022555


Mus musculus

Features
Gene ID: ENSMUSG00000022555
  
Biological name :Dgat1
  
Synonyms : Dgat1 / Diacylglycerol O-acyltransferase 1 / Q9Z2A7
  
Possible biological names infered from orthology : O75907
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 76502015
Gene end: 76511953
  
Corresponding Affymetrix probe sets: 10429926 (MoGene1.0st)   1418295_s_at (Mouse Genome 430 2.0 Array)   1445229_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023214
NCBI entrez gene - 13350     See in Manteia.
MGI - MGI:1333825
RefSeq - XM_017316426
RefSeq - NM_010046
RefSeq - XM_006520405
RefSeq Peptide - NP_034176
swissprot - Q9Z2A7
swissprot - Q54AA6
Ensembl - ENSMUSG00000022555
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgat1aENSDARG00000103503Danio rerio
 dgat1bENSDARG00000054914Danio rerio
 DGAT1ENSG00000185000Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Soat1 / Q61263 / Sterol O-acyltransferase 1 / P35610*ENSMUSG0000002660021
Soat2 / O88908 / Sterol O-acyltransferase 2 / O75908*ENSMUSG0000002304520


Protein motifs (from Interpro)
Interpro ID Name
 IPR004299  Membrane bound O-acyl transferase, MBOAT
 IPR014371  Sterol O-acyltransferase, ACAT/DAG/ARE types
 IPR027251  Diacylglycerol O-acyltransferase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019432 triglyceride biosynthetic process IDA
 biological_processGO:0019915 lipid storage IGI
 biological_processGO:0034379 very-low-density lipoprotein particle assembly IEA
 biological_processGO:0035336 long-chain fatty-acyl-CoA metabolic process IDA
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0046339 diacylglycerol metabolic process IDA
 biological_processGO:0046486 glycerolipid metabolic process IEA
 biological_processGO:0055089 fatty acid homeostasis IGI
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IMP
 molecular_functionGO:0003846 2-acylglycerol O-acyltransferase activity IDA
 molecular_functionGO:0004144 diacylglycerol O-acyltransferase activity IDA
 molecular_functionGO:0008374 O-acyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0050252 retinol O-fatty-acyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodeling of DAG and TAG
Neutrophil degranulation
Triglyceride biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

Allelic Composition: Dgat1tm2Far/Dgat1tm2Far,Tg(KRT14-cre)1Amc/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxp3tm3(DTR/GFP)Ayr/Foxp3+,Gpr174tm1Cys/Gpr174+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm3(DTR/GFP)Ayr/Foxp3+,Gpr174tm1Cys/Gpr174+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mogat2tm1.1Ryyo/Mogat2tm1.1Ryyo
Genetic Background: B6.Cg-Mogat2tm1.1Ryyo

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mogat2tm1.1Ryyo/Mogat2tm1.1Ryyo
Genetic Background: B6.Cg-Mogat2tm1.1Ryyo

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxp3tm3(DTR/GFP)Ayr/Foxp3+,Gpr174tm1Cys/Gpr174+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm3(DTR/GFP)Ayr/Foxp3+,Gpr174tm1Cys/Gpr174+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0008861 abnormal hair shedding "anomaly in the hair cycle changes the timing of the hair loss that normally follows the anagen phase" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0009297 decreased mammary fat pad weight 
Show

Allelic Composition: Foxp3tm3(DTR/GFP)Ayr/Foxp3+,Gpr174tm1Cys/Gpr174+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm3(DTR/GFP)Ayr/Foxp3+,Gpr174tm1Cys/Gpr174+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm3(DTR/GFP)Ayr/Foxp3+,Gpr174tm1Cys/Gpr174+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010174 decreased mammary gland epithelium proliferation "decrease in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp3tm3(DTR/GFP)Ayr/Foxp3+,Gpr174tm1Cys/Gpr174+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

Allelic Composition: Dgat1tm1Far/Dgat1tm1Far
Genetic Background: B6J.129S4-Dgat1tm1Far

 MP:0011232 abnormal vitamin A level "any anomaly in the concentration of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet" [GO:0035238]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0012075 impaired mammary gland growth during pregnancy "defect in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation" [MGI:llw2]
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Allelic Composition: Dgat1tm1Far/Dgat1tm1Far
Genetic Background: B6J.129S4-Dgat1tm1Far

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022555 Dgat1 / Q9Z2A7 / Diacylglycerol O-acyltransferase 1 / O75907*  / complex






 

1 s.

 
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