ENSG00000065665


Homo sapiens

Features
Gene ID: ENSG00000065665
  
Biological name :SEC61A2
  
Synonyms : Q9H9S3 / SEC61A2 / Sec61 translocon alpha 2 subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p14
Gene start: 12129637
Gene end: 12169961
  
Corresponding Affymetrix probe sets: 219499_at (Human Genome U133 Plus 2.0 Array)   228747_at (Human Genome U133 Plus 2.0 Array)   230215_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402124
Ensembl peptide - ENSP00000436749
Ensembl peptide - ENSP00000436294
Ensembl peptide - ENSP00000404959
Ensembl peptide - ENSP00000298428
Ensembl peptide - ENSP00000302048
Ensembl peptide - ENSP00000368302
Ensembl peptide - ENSP00000368306
Ensembl peptide - ENSP00000368319
Ensembl peptide - ENSP00000368339
Ensembl peptide - ENSP00000393214
Ensembl peptide - ENSP00000401731
NCBI entrez gene - 55176     See in Manteia.
RefSeq - NM_018144
RefSeq - NM_001142627
RefSeq - NM_001142628
RefSeq Peptide - NP_001136099
RefSeq Peptide - NP_001136100
RefSeq Peptide - NP_060614
swissprot - H7C1Q9
swissprot - H7C1S8
swissprot - Q8TC24
swissprot - C9JJV4
swissprot - Q9H9S3
swissprot - A6NK38
swissprot - A6NIF9
swissprot - F2Z2C7
swissprot - F8W776
swissprot - H7C069
Ensembl - ENSG00000065665
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEC61A2ENSGALG00000036300Gallus gallus
 Q9JLR1ENSMUSG00000025816Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P61619 / SEC61A1 / Sec61 translocon alpha 1 subunitENSG0000005826293


Protein motifs (from Interpro)
Interpro ID Name
 IPR002208  SecY/SEC61-alpha family
 IPR019561  Translocon Sec61/SecY, plug domain
 IPR023201  SecY domain superfamily
 IPR030659  SecY conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0043022 ribosome binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
SRP-dependent cotranslational protein targeting to membrane
XBP1(S) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106803 P60468 / SEC61B / Sec61 translocon beta subunit  / complex
 ENSG00000058262 P61619 / SEC61A1 / Sec61 translocon alpha 1 subunit  / complex
 ENSG00000008952 SEC62 / Q99442 / SEC62 homolog, preprotein translocation factor  / complex
 ENSG00000025796 SEC63 / Q9UGP8 / SEC63 homolog, protein translocation regulator  / complex
 ENSG00000132432 P60059 / SEC61G / Sec61 translocon gamma subunit  / complex
 ENSG00000198356 ASNA1 / O43681 / arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)  / reaction






 

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