ENSG00000072315


Homo sapiens

Features
Gene ID: ENSG00000072315
  
Biological name :TRPC5
  
Synonyms : Q9UL62 / transient receptor potential cation channel subfamily C member 5 / TRPC5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q23
Gene start: 111774315
Gene end: 112082776
  
Corresponding Affymetrix probe sets: 220552_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262839
NCBI entrez gene - 7224     See in Manteia.
OMIM - 300334
RefSeq - NM_012471
RefSeq - XM_017029774
RefSeq Peptide - NP_036603
swissprot - Q9UL62
Ensembl - ENSG00000072315
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpc5aENSDARG00000070504Danio rerio
 trpc5bENSDARG00000060837Danio rerio
 TRPC5ENSGALG00000007972Gallus gallus
 Trpc5ENSMUSG00000041710Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRPC4 / Q9UBN4 / transient receptor potential cation channel subfamily C member 4ENSG0000013310766
TRPC1 / P48995 / transient receptor potential cation channel subfamily C member 1ENSG0000014493535
TRPC3 / Q13507 / transient receptor potential cation channel subfamily C member 3ENSG0000013874133
TRPC7 / Q9HCX4 / transient receptor potential cation channel subfamily C member 7ENSG0000006901832
TRPC6 / Q9Y210 / transient receptor potential cation channel subfamily C member 6ENSG0000013767232


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR002153  Transient receptor potential channel, canonical
 IPR004729  Transient receptor potential channel
 IPR005461  Transient receptor potential channel, canonical 5
 IPR005821  Ion transport domain
 IPR013555  Transient receptor ion channel domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport TAS
 biological_processGO:0006828 manganese ion transport IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport TAS
 biological_processGO:1902630 regulation of membrane hyperpolarization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0034704 calcium channel complex IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015279 store-operated calcium channel activity TAS
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0042805 actinin binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
TRP channels
Role of second messengers in netrin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137672 TRPC6 / Q9Y210 / transient receptor potential cation channel subfamily C member 6  / complex
 ENSG00000069018 TRPC7 / Q9HCX4 / transient receptor potential cation channel subfamily C member 7  / complex
 ENSG00000144935 TRPC1 / P48995 / transient receptor potential cation channel subfamily C member 1  / complex
 ENSG00000138741 TRPC3 / Q13507 / transient receptor potential cation channel subfamily C member 3  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr