ENSG00000133107


Homo sapiens

Features
Gene ID: ENSG00000133107
  
Biological name :TRPC4
  
Synonyms : Q9UBN4 / transient receptor potential cation channel subfamily C member 4 / TRPC4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q13.3
Gene start: 37636636
Gene end: 37870425
  
Corresponding Affymetrix probe sets: 220817_at (Human Genome U133 Plus 2.0 Array)   220818_s_at (Human Genome U133 Plus 2.0 Array)   224219_s_at (Human Genome U133 Plus 2.0 Array)   224220_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486109
Ensembl peptide - ENSP00000342580
Ensembl peptide - ENSP00000348025
Ensembl peptide - ENSP00000351264
Ensembl peptide - ENSP00000368995
Ensembl peptide - ENSP00000369001
Ensembl peptide - ENSP00000410133
Ensembl peptide - ENSP00000435969
Ensembl peptide - ENSP00000369027
NCBI entrez gene - 7223     See in Manteia.
OMIM - 603651
RefSeq - XM_017020724
RefSeq - NM_001135955
RefSeq - NM_001135956
RefSeq - NM_001135957
RefSeq - NM_001135958
RefSeq - NM_003306
RefSeq - NM_016179
RefSeq - XM_011535206
RefSeq - XM_017020723
RefSeq Peptide - NP_001129430
RefSeq Peptide - NP_003297
RefSeq Peptide - NP_057263
RefSeq Peptide - NP_001129428
RefSeq Peptide - NP_001129429
RefSeq Peptide - NP_001129427
swissprot - Q3MHB9
swissprot - Q9UBN4
Ensembl - ENSG00000133107
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpc4aENSDARG00000070507Danio rerio
 trpc4bENSDARG00000102017Danio rerio
 TRPC4ENSGALG00000017044Gallus gallus
 Trpc4ENSMUSG00000027748Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRPC5 / Q9UL62 / transient receptor potential cation channel subfamily C member 5ENSG0000007231566
TRPC1 / P48995 / transient receptor potential cation channel subfamily C member 1ENSG0000014493536
TRPC7 / Q9HCX4 / transient receptor potential cation channel subfamily C member 7ENSG0000006901833
TRPC6 / Q9Y210 / transient receptor potential cation channel subfamily C member 6ENSG0000013767233
TRPC3 / Q13507 / transient receptor potential cation channel subfamily C member 3ENSG0000013874132


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR002153  Transient receptor potential channel, canonical
 IPR004729  Transient receptor potential channel
 IPR005460  Transient receptor potential channel, canonical 4
 IPR005821  Ion transport domain
 IPR013555  Transient receptor ion channel domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport TAS
 biological_processGO:0006828 manganese ion transport IBA
 biological_processGO:0014051 gamma-aminobutyric acid secretion IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070509 calcium ion import IDA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 cellular_componentGO:0034704 calcium channel complex IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0015279 store-operated calcium channel activity IMP
 molecular_functionGO:0045296 cadherin binding IPI
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
TRP channels
Role of second messengers in netrin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138741 TRPC3 / Q13507 / transient receptor potential cation channel subfamily C member 3  / complex
 ENSG00000069018 TRPC7 / Q9HCX4 / transient receptor potential cation channel subfamily C member 7  / complex
 ENSG00000137672 TRPC6 / Q9Y210 / transient receptor potential cation channel subfamily C member 6  / complex
 ENSG00000144935 TRPC1 / P48995 / transient receptor potential cation channel subfamily C member 1  / complex






 

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