ENSMUSG00000027748


Mus musculus

Features
Gene ID: ENSMUSG00000027748
  
Biological name :Trpc4
  
Synonyms : Q9QUQ5 / transient receptor potential cation channel, subfamily C, member 4 / Trpc4
  
Possible biological names infered from orthology : Q9UBN4
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: C
Gene start: 54156035
Gene end: 54318471
  
Corresponding Affymetrix probe sets: 10492006 (MoGene1.0st)   1423579_a_at (Mouse Genome 430 2.0 Array)   1446366_at (Mouse Genome 430 2.0 Array)   1451033_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029311
Ensembl peptide - ENSMUSP00000142921
Ensembl peptide - ENSMUSP00000143593
NCBI entrez gene - 22066     See in Manteia.
MGI - MGI:109525
RefSeq - XM_017319534
RefSeq - NM_001253682
RefSeq - NM_016984
RefSeq - XM_006501296
RefSeq - XM_006501297
RefSeq - XM_006501298
RefSeq Peptide - NP_001240611
RefSeq Peptide - NP_058680
swissprot - Q9QUQ5
swissprot - A0A0G2JEV6
swissprot - Q0VB97
Ensembl - ENSMUSG00000027748
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpc4aENSDARG00000070507Danio rerio
 trpc4bENSDARG00000102017Danio rerio
 TRPC4ENSGALG00000017044Gallus gallus
 TRPC4ENSG00000133107Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpc5 / Q9QX29 / transient receptor potential cation channel, subfamily C, member 5 / Q9UL62*ENSMUSG0000004171066
Trpc1 / transient receptor potential cation channel, subfamily C, member 1 / P48995*ENSMUSG0000003283936
Trpc7 / Q9WVC5 / transient receptor potential cation channel, subfamily C, member 7 / Q9HCX4*ENSMUSG0000002154133
Trpc6 / Q61143 / transient receptor potential cation channel, subfamily C, member 6 / Q9Y210*ENSMUSG0000003199733
Trpc3 / transient receptor potential cation channel, subfamily C, member 3 / Q13507*ENSMUSG0000002771632
Xntrpc / Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthroughENSMUSG0000007042529
Trpc2 / Q9R244 / Short transient receptor potential channel 2 ENSMUSG0000010025428


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR002153  Transient receptor potential channel, canonical
 IPR004729  Transient receptor potential channel
 IPR005460  Transient receptor potential channel, canonical 4
 IPR005821  Ion transport domain
 IPR013555  Transient receptor ion channel domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006828 manganese ion transport IBA
 biological_processGO:0014051 gamma-aminobutyric acid secretion IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070509 calcium ion import ISO
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0030863 cortical cytoskeleton ISO
 cellular_componentGO:0034704 calcium channel complex ISO
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0015279 store-operated calcium channel activity ISO
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IDA


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Trpc5tm1.1Lbi/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Trpc4tm1.1Clph/Trpc4tm1.1Clph
Genetic Background: 129S1/Sv-Trpc4tm1.1Clph

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Trpc4tm1.1Clph/Trpc4tm1.1Clph
Genetic Background: 129S1/Sv-Trpc4tm1.1Clph

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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