ENSMUSG00000027716


Mus musculus

Features
Gene ID: ENSMUSG00000027716
  
Biological name :Trpc3
  
Synonyms : transient receptor potential cation channel, subfamily C, member 3 / Trpc3
  
Possible biological names infered from orthology : Q13507
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: B
Gene start: 36620482
Gene end: 36690167
  
Corresponding Affymetrix probe sets: 10497862 (MoGene1.0st)   1417577_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029271
NCBI entrez gene - 22065     See in Manteia.
MGI - MGI:109526
RefSeq - NM_019510
RefSeq - XM_006535439
RefSeq Peptide - NP_062383
swissprot - B1ATV3
Ensembl - ENSMUSG00000027716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpc3ENSDARG00000098291Danio rerio
 TRPC3ENSGALG00000011875Gallus gallus
 TRPC3ENSG00000138741Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpc7 / Q9WVC5 / transient receptor potential cation channel, subfamily C, member 7 / Q9HCX4*ENSMUSG0000002154174
Trpc6 / Q61143 / transient receptor potential cation channel, subfamily C, member 6 / Q9Y210*ENSMUSG0000003199769
Trpc4 / Q9QUQ5 / transient receptor potential cation channel, subfamily C, member 4 / Q9UBN4*ENSMUSG0000002774835
Trpc5 / Q9QX29 / transient receptor potential cation channel, subfamily C, member 5 / Q9UL62*ENSMUSG0000004171035
Xntrpc / Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthroughENSMUSG0000007042534
Trpc2 / Q9R244 / Short transient receptor potential channel 2 ENSMUSG0000010025432
Trpc1 / transient receptor potential cation channel, subfamily C, member 1 / P48995*ENSMUSG0000003283931


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR002153  Transient receptor potential channel, canonical
 IPR004729  Transient receptor potential channel
 IPR005459  Transient receptor potential channel, canonical 3
 IPR005821  Ion transport domain
 IPR013555  Transient receptor ion channel domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IEA
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Trpc3Mwk/Trpc3+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Trpc3Mwk/Trpc3+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Megf8hlb611/Megf8hlb611
Genetic Background: involves: C57BL/6J * C3H/HeJ

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Trpc3Mwk/Trpc3+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Trpc3Mwk/Trpc3+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Megf8hlb611/Megf8hlb611
Genetic Background: involves: C57BL/6J * C3H/HeJ

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trpc3Mwk/Trpc3+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: C4btm1Crr/C4btm1Crr
Genetic Background: involves: 129S4/SvJae

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trpc3Mwk/Trpc3+
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0011176 abnormal erythroblast morphology "any structural anomaly of the nucleated precursor of erythrocytes" [ISBN:0-683-40008-8]
Show

Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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