ENSMUSG00000031997


Mus musculus

Features
Gene ID: ENSMUSG00000031997
  
Biological name :Trpc6
  
Synonyms : Q61143 / transient receptor potential cation channel, subfamily C, member 6 / Trpc6
  
Possible biological names infered from orthology : Q9Y210
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A1
Gene start: 8544142
Gene end: 8680741
  
Corresponding Affymetrix probe sets: 10583163 (MoGene1.0st)   1449431_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057965
Ensembl peptide - ENSMUSP00000149686
Ensembl peptide - ENSMUSP00000150193
NCBI entrez gene - 22068     See in Manteia.
MGI - MGI:109523
RefSeq - XM_011242360
RefSeq - NM_001282086
RefSeq - NM_001282087
RefSeq - NM_013838
RefSeq - XM_006509849
RefSeq - XM_006509850
RefSeq - XM_011242359
RefSeq Peptide - NP_001269015
RefSeq Peptide - NP_001269016
RefSeq Peptide - NP_038866
swissprot - Q61143
swissprot - Q6NV56
swissprot - Q3UZG1
Ensembl - ENSMUSG00000031997
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpc6aENSDARG00000056625Danio rerio
 trpc6bENSDARG00000067730Danio rerio
 TRPC6ENSGALG00000029416Gallus gallus
 TRPC6ENSG00000137672Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpc7 / Q9WVC5 / transient receptor potential cation channel, subfamily C, member 7 / Q9HCX4*ENSMUSG0000002154169
Trpc3 / transient receptor potential cation channel, subfamily C, member 3 / Q13507*ENSMUSG0000002771667
Trpc4 / Q9QUQ5 / transient receptor potential cation channel, subfamily C, member 4 / Q9UBN4*ENSMUSG0000002774835
Trpc5 / Q9QX29 / transient receptor potential cation channel, subfamily C, member 5 / Q9UL62*ENSMUSG0000004171034
Xntrpc / Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthroughENSMUSG0000007042533
Trpc2 / Q9R244 / Short transient receptor potential channel 2 ENSMUSG0000010025431
Trpc1 / transient receptor potential cation channel, subfamily C, member 1 / P48995*ENSMUSG0000003283930


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR002153  Transient receptor potential channel, canonical
 IPR004729  Transient receptor potential channel
 IPR005462  Transient receptor potential channel, canonical 6
 IPR005821  Ion transport domain
 IPR013555  Transient receptor ion channel domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006828 manganese ion transport IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007338 single fertilization IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0032414 positive regulation of ion transmembrane transporter activity ISO
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0036057 slit diaphragm IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0015279 store-operated calcium channel activity IDA
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042805 actinin binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000250 abnormal vasoconstriction "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: C4btm1Crr/C4btm1Crr
Genetic Background: involves: 129S4/SvJae

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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