ENSG00000069018


Homo sapiens

Features
Gene ID: ENSG00000069018
  
Biological name :TRPC7
  
Synonyms : Q9HCX4 / transient receptor potential cation channel subfamily C member 7 / TRPC7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.1
Gene start: 136213320
Gene end: 136365545
  
Corresponding Affymetrix probe sets: 208589_at (Human Genome U133 Plus 2.0 Array)   234407_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000367720
Ensembl peptide - ENSP00000426070
Ensembl peptide - ENSP00000330322
Ensembl peptide - ENSP00000426870
Ensembl peptide - ENSP00000421571
Ensembl peptide - ENSP00000424854
NCBI entrez gene - 57113     See in Manteia.
RefSeq - NM_001167576
RefSeq - NM_001167577
RefSeq - NM_020389
RefSeq Peptide - NP_065122
RefSeq Peptide - NP_001161048
RefSeq Peptide - NP_001161049
swissprot - Q9HCX4
swissprot - Q70T24
swissprot - A1A4Z5
swissprot - Q70T25
Ensembl - ENSG00000069018
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpc7aENSDARG00000027523Danio rerio
 trpc7bENSDARG00000079469Danio rerio
 TRPC7ENSGALG00000006297Gallus gallus
 Trpc7ENSMUSG00000021541Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRPC3 / Q13507 / transient receptor potential cation channel subfamily C member 3ENSG0000013874179
TRPC6 / Q9Y210 / transient receptor potential cation channel subfamily C member 6ENSG0000013767275
TRPC4 / Q9UBN4 / transient receptor potential cation channel subfamily C member 4ENSG0000013310737
TRPC5 / Q9UL62 / transient receptor potential cation channel subfamily C member 5ENSG0000007231536
TRPC1 / P48995 / transient receptor potential cation channel subfamily C member 1ENSG0000014493532


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR002153  Transient receptor potential channel, canonical
 IPR004729  Transient receptor potential channel
 IPR005463  Transient receptor potential channel, canonical 7
 IPR005821  Ion transport domain
 IPR013555  Transient receptor ion channel domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006828 manganese ion transport IBA
 biological_processGO:0007338 single fertilization IBA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005801 cis-Golgi network IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015279 store-operated calcium channel activity IBA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
TRP channels
Role of second messengers in netrin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072315 TRPC5 / Q9UL62 / transient receptor potential cation channel subfamily C member 5  / complex
 ENSG00000144935 TRPC1 / P48995 / transient receptor potential cation channel subfamily C member 1  / complex
 ENSG00000133107 TRPC4 / Q9UBN4 / transient receptor potential cation channel subfamily C member 4  / complex






 

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