ENSG00000144935


Homo sapiens

Features
Gene ID: ENSG00000144935
  
Biological name :TRPC1
  
Synonyms : P48995 / transient receptor potential cation channel subfamily C member 1 / TRPC1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q23
Gene start: 142724074
Gene end: 142807888
  
Corresponding Affymetrix probe sets: 205802_at (Human Genome U133 Plus 2.0 Array)   205803_s_at (Human Genome U133 Plus 2.0 Array)   211602_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000273482
Ensembl peptide - ENSP00000418708
Ensembl peptide - ENSP00000419313
Ensembl peptide - ENSP00000481537
NCBI entrez gene - 7220     See in Manteia.
OMIM - 602343
RefSeq - XM_017007122
RefSeq - NM_001251845
RefSeq - NM_003304
RefSeq - XM_005247738
RefSeq - XM_005247739
RefSeq - XM_017007121
RefSeq Peptide - NP_001238774
RefSeq Peptide - NP_003295
swissprot - H7C508
swissprot - P48995
Ensembl - ENSG00000144935
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpc1ENSDARG00000061203Danio rerio
 TRPC1ENSGALG00000002639Gallus gallus
 Trpc1ENSMUSG00000032839Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRPC4 / Q9UBN4 / transient receptor potential cation channel subfamily C member 4ENSG0000013310745
TRPC5 / Q9UL62 / transient receptor potential cation channel subfamily C member 5ENSG0000007231543
TRPC6 / Q9Y210 / transient receptor potential cation channel subfamily C member 6ENSG0000013767236
TRPC7 / Q9HCX4 / transient receptor potential cation channel subfamily C member 7ENSG0000006901835
TRPC3 / Q13507 / transient receptor potential cation channel subfamily C member 3ENSG0000013874135


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR002153  Transient receptor potential channel, canonical
 IPR004729  Transient receptor potential channel
 IPR005457  Transient receptor potential channel, canonical 1
 IPR005821  Ion transport domain
 IPR013555  Transient receptor ion channel domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport TAS
 biological_processGO:0006828 manganese ion transport IBA
 biological_processGO:0042438 melanin biosynthetic process IDA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0051592 response to calcium ion IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport TAS
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity EXP
 molecular_functionGO:0005262 calcium channel activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015279 store-operated calcium channel activity TAS
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IDA


Pathways (from Reactome)
Pathway description
TRP channels
Role of second messengers in netrin-1 signaling
Ion homeostasis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072315 TRPC5 / Q9UL62 / transient receptor potential cation channel subfamily C member 5  / complex
 ENSG00000137672 TRPC6 / Q9Y210 / transient receptor potential cation channel subfamily C member 6  / complex
 ENSG00000138741 TRPC3 / Q13507 / transient receptor potential cation channel subfamily C member 3  / complex
 ENSG00000167323 STIM1 / Q13586 / stromal interaction molecule 1  / reaction / complex
 ENSG00000069018 TRPC7 / Q9HCX4 / transient receptor potential cation channel subfamily C member 7  / complex
 ENSG00000133107 TRPC4 / Q9UBN4 / transient receptor potential cation channel subfamily C member 4  / complex






 

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