ENSG00000074696


Homo sapiens

Features
Gene ID: ENSG00000074696
  
Biological name :HACD3
  
Synonyms : 3-hydroxyacyl-CoA dehydratase 3 / HACD3 / Q9P035
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q22.31
Gene start: 65530418
Gene end: 65578352
  
Corresponding Affymetrix probe sets: 217777_s_at (Human Genome U133 Plus 2.0 Array)   222404_x_at (Human Genome U133 Plus 2.0 Array)   222405_at (Human Genome U133 Plus 2.0 Array)   234000_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456300
Ensembl peptide - ENSP00000456568
Ensembl peptide - ENSP00000261875
Ensembl peptide - ENSP00000392491
Ensembl peptide - ENSP00000454610
Ensembl peptide - ENSP00000454873
Ensembl peptide - ENSP00000455530
Ensembl peptide - ENSP00000455587
Ensembl peptide - ENSP00000455686
NCBI entrez gene - 51495     See in Manteia.
OMIM - 615940
RefSeq - XM_011521664
RefSeq - NM_016395
RefSeq Peptide - NP_057479
swissprot - H3BRL8
swissprot - H3BS72
swissprot - H3BMZ1
swissprot - Q9P035
swissprot - H3BPZ1
Ensembl - ENSG00000074696
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hacd3ENSDARG00000016038Danio rerio
 HACD3ENSGALG00000007481Gallus gallus
 Hacd3ENSMUSG00000033629Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HACD4 / Q5VWC8 / 3-hydroxyacyl-CoA dehydratase 4ENSG0000018892126
HACD1 / B0YJ81 / 3-hydroxyacyl-CoA dehydratase 1ENSG0000016599618
HACD2 / Q6Y1H2 / 3-hydroxyacyl-CoA dehydratase 2ENSG0000020652717


Protein motifs (from Interpro)
Interpro ID Name
 IPR007052  CS domain
 IPR007482  Protein-tyrosine phosphatase-like, PTPLA
 IPR008978  HSP20-like chaperone


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0007257 activation of JUN kinase activity TAS
 biological_processGO:0007264 small GTPase mediated signal transduction TAS
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0016601 Rac protein signal transduction NAS
 biological_processGO:0030148 sphingolipid biosynthetic process IBA
 biological_processGO:0030497 fatty acid elongation IDA
 biological_processGO:0042761 very long-chain fatty acid biosynthetic process IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045070 positive regulation of viral genome replication IMP
 biological_processGO:0046726 positive regulation by virus of viral protein levels in host cell IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IBA
 cellular_componentGO:0031965 nuclear membrane IDA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0018812 3-hydroxyacyl-CoA dehydratase activity IDA
 molecular_functionGO:0019899 enzyme binding IDA
 molecular_functionGO:0102158 very-long-chain 3-hydroxyacyl-CoA dehydratase activity IEA
 molecular_functionGO:0102343 3-hydroxy-arachidoyl-CoA dehydratase activity IEA
 molecular_functionGO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity IEA
 molecular_functionGO:0102345 3-hydroxy-lignoceroyl-CoA dehydratase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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