ENSG00000076555


Homo sapiens

Features
Gene ID: ENSG00000076555
  
Biological name :ACACB
  
Synonyms : ACACB / acetyl-CoA carboxylase beta / O00763
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.11
Gene start: 109116595
Gene end: 109268226
  
Corresponding Affymetrix probe sets: 1552615_at (Human Genome U133 Plus 2.0 Array)   1552616_a_at (Human Genome U133 Plus 2.0 Array)   214584_x_at (Human Genome U133 Plus 2.0 Array)   221928_at (Human Genome U133 Plus 2.0 Array)   43427_at (Human Genome U133 Plus 2.0 Array)   49452_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474680
Ensembl peptide - ENSP00000443494
Ensembl peptide - ENSP00000478488
Ensembl peptide - ENSP00000341044
Ensembl peptide - ENSP00000367079
Ensembl peptide - ENSP00000367085
Ensembl peptide - ENSP00000443281
NCBI entrez gene - 32     See in Manteia.
OMIM - 601557
RefSeq - XM_017019252
RefSeq - NM_001093
RefSeq - XM_005253876
RefSeq - XM_006719367
RefSeq - XM_011538259
RefSeq - XM_011538263
RefSeq - XM_011538264
RefSeq Peptide - NP_001084
swissprot - F5H5C3
swissprot - F8W8T8
swissprot - S4R3S7
swissprot - A0A087WUA1
swissprot - O00763
swissprot - H0YGH5
Ensembl - ENSG00000076555
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acacbENSDARG00000061994Danio rerio
 ENSGALG00000005043Gallus gallus
 AcacbENSMUSG00000042010Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACACA / Q13085 / acetyl-CoA carboxylase alphaENSG0000027854071


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR005479  Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
 IPR005481  Biotin carboxylase-like, N-terminal domain
 IPR005482  Biotin carboxylase, C-terminal
 IPR011053  Single hybrid motif
 IPR011054  Rudiment single hybrid motif
 IPR011761  ATP-grasp fold
 IPR011762  Acetyl-coenzyme A carboxyltransferase, N-terminal
 IPR011763  Acetyl-coenzyme A carboxyltransferase, C-terminal
 IPR011764  Biotin carboxylation domain
 IPR013537  Acetyl-CoA carboxylase, central domain
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR029045  ClpP/crotonase-like domain superfamily
 IPR034733  Acetyl-CoA carboxylase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006084 acetyl-CoA metabolic process IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006768 biotin metabolic process TAS
 biological_processGO:0006853 carnitine shuttle TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010884 positive regulation of lipid storage IEA
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0031325 positive regulation of cellular metabolic process TAS
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0031999 negative regulation of fatty acid beta-oxidation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0046322 negative regulation of fatty acid oxidation IEA
 biological_processGO:0050995 negative regulation of lipid catabolic process IEA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0060421 positive regulation of heart growth IEA
 biological_processGO:0097009 energy homeostasis IEA
 biological_processGO:2001295 malonyl-CoA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003989 acetyl-CoA carboxylase activity IEA
 molecular_functionGO:0004075 biotin carboxylase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009374 biotin binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ChREBP activates metabolic gene expression
Biotin transport and metabolism
Import of palmitoyl-CoA into the mitochondrial matrix
Activation of gene expression by SREBF (SREBP)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000159267 HLCS / P50747 / holocarboxylase synthetase  / reaction
 ENSG00000076555 ACACB / O00763 / acetyl-CoA carboxylase beta  / -






 

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