ENSMUSG00000042010


Mus musculus

Features
Gene ID: ENSMUSG00000042010
  
Biological name :Acacb
  
Synonyms : Acacb / acetyl-Coenzyme A carboxylase beta / E9Q4Z2
  
Possible biological names infered from orthology : acetyl-CoA carboxylase beta / O00763
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 114146535
Gene end: 114250761
  
Corresponding Affymetrix probe sets: 10524460 (MoGene1.0st)   1427052_at (Mouse Genome 430 2.0 Array)   1445754_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099642
Ensembl peptide - ENSMUSP00000115432
Ensembl peptide - ENSMUSP00000031583
NCBI entrez gene - 100705     See in Manteia.
MGI - MGI:2140940
RefSeq - XM_006530114
RefSeq - XM_006530111
RefSeq - XM_006530112
RefSeq - XM_006530113
RefSeq - NM_133904
RefSeq Peptide - NP_598665
swissprot - D3Z0B3
swissprot - E9Q4Z2
Ensembl - ENSMUSG00000042010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acacbENSDARG00000061994Danio rerio
 ENSGALG00000005043Gallus gallus
 ACACBENSG00000076555Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acaca / Q5SWU9 / acetyl-Coenzyme A carboxylase alpha / Q13085* / acetyl-CoA carboxylase alpha*ENSMUSG0000002053270


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR005479  Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
 IPR005481  Biotin carboxylase-like, N-terminal domain
 IPR005482  Biotin carboxylase, C-terminal
 IPR011053  Single hybrid motif
 IPR011054  Rudiment single hybrid motif
 IPR011761  ATP-grasp fold
 IPR011762  Acetyl-coenzyme A carboxyltransferase, N-terminal
 IPR011763  Acetyl-coenzyme A carboxyltransferase, C-terminal
 IPR011764  Biotin carboxylation domain
 IPR013537  Acetyl-CoA carboxylase, central domain
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR029045  ClpP/crotonase-like domain superfamily
 IPR034733  Acetyl-CoA carboxylase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006084 acetyl-CoA metabolic process ISO
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010884 positive regulation of lipid storage IMP
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0031667 response to nutrient levels IMP
 biological_processGO:0031999 negative regulation of fatty acid beta-oxidation IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043086 negative regulation of catalytic activity IDA
 biological_processGO:0046322 negative regulation of fatty acid oxidation IMP
 biological_processGO:0050995 negative regulation of lipid catabolic process IMP
 biological_processGO:0051289 protein homotetramerization ISO
 biological_processGO:0060421 positive regulation of heart growth IMP
 biological_processGO:0097009 energy homeostasis IMP
 biological_processGO:2001295 malonyl-CoA biosynthetic process IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003989 acetyl-CoA carboxylase activity ISO
 molecular_functionGO:0004075 biotin carboxylase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009374 biotin binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ChREBP activates metabolic gene expression
Biotin transport and metabolism
Import of palmitoyl-CoA into the mitochondrial matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Acacbtm1.2Lowl/Acacbtm1.2Lowl
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Socs3tm1Wsa/Socs3tm2Wsa,Lyz2tm1(cre)Ifo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acacbtm1.2Lowl/Acacbtm1.2Lowl
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Acacbtm1.2Lowl/Acacbtm1.2Lowl
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acacbtm1.2Lowl/Acacbtm1.2Lowl
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0014173 increased fatty acid beta-oxidation "increased rate or incidence of the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042010 Acacb / E9Q4Z2 / acetyl-Coenzyme A carboxylase beta / O00763* / acetyl-CoA carboxylase beta*  / -
 ENSMUSG00000040820 Hlcs / Q920N2 / holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) / P50747* / holocarboxylase synthetase*  / reaction






 

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