ENSMUSG00000020532


Mus musculus

Features
Gene ID: ENSMUSG00000020532
  
Biological name :Acaca
  
Synonyms : Acaca / acetyl-Coenzyme A carboxylase alpha / Q5SWU9
  
Possible biological names infered from orthology : acetyl-CoA carboxylase alpha / Q13085
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 84129672
Gene end: 84401651
  
Corresponding Affymetrix probe sets: 10379820 (MoGene1.0st)   10394538 (MoGene1.0st)   1427595_at (Mouse Genome 430 2.0 Array)   1434185_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139378
Ensembl peptide - ENSMUSP00000117972
Ensembl peptide - ENSMUSP00000121274
Ensembl peptide - ENSMUSP00000020843
Ensembl peptide - ENSMUSP00000099490
Ensembl peptide - ENSMUSP00000116174
Ensembl peptide - ENSMUSP00000116295
NCBI entrez gene - 107476     See in Manteia.
MGI - MGI:108451
RefSeq - XM_011248667
RefSeq - NM_133360
RefSeq - XM_006531953
RefSeq - XM_006531954
RefSeq - XM_006531955
RefSeq - XM_006531956
RefSeq - XM_006531957
RefSeq - XM_006531958
RefSeq - XM_011248666
RefSeq Peptide - NP_579938
swissprot - Q5SWU9
swissprot - V9GWR9
swissprot - V9GWS0
swissprot - V9GWS1
swissprot - V9GXY1
swissprot - A0A0R4J1S9
Ensembl - ENSMUSG00000020532
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acacaENSDARG00000078512Danio rerio
 ACACAENSGALG00000005439Gallus gallus
 ACACAENSG00000278540Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acacb / E9Q4Z2 / acetyl-Coenzyme A carboxylase beta / O00763* / acetyl-CoA carboxylase beta*ENSMUSG0000004201073


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001882  Biotin-binding site
 IPR005479  Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
 IPR005481  Biotin carboxylase-like, N-terminal domain
 IPR005482  Biotin carboxylase, C-terminal
 IPR011053  Single hybrid motif
 IPR011054  Rudiment single hybrid motif
 IPR011761  ATP-grasp fold
 IPR011762  Acetyl-coenzyme A carboxyltransferase, N-terminal
 IPR011763  Acetyl-coenzyme A carboxyltransferase, C-terminal
 IPR011764  Biotin carboxylation domain
 IPR013537  Acetyl-CoA carboxylase, central domain
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR029045  ClpP/crotonase-like domain superfamily
 IPR034733  Acetyl-CoA carboxylase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0006084 acetyl-CoA metabolic process IDA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0055088 lipid homeostasis IMP
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IDA
 biological_processGO:2001295 malonyl-CoA biosynthetic process IEA
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0015629 actin cytoskeleton ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003989 acetyl-CoA carboxylase activity IMP
 molecular_functionGO:0004075 biotin carboxylase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ChREBP activates metabolic gene expression
Biotin transport and metabolism
Import of palmitoyl-CoA into the mitochondrial matrix
Fatty acyl-CoA biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acacatm2Sjw/Acacatm2Sjw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acacatm2Sjw/Acacatm2Sjw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Acacatm2Sjw/Acacatm2Sjw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acacatm2Sjw/Acacatm2Sjw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acacatm2Sjw/Acacatm2Sjw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou1f1dw/Pou1f1dw-J
Genetic Background: (DW/J x C3H/HeJ)F1

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acacatm2Sjw/Acacatm2Sjw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acacatm2Sjw/Acacatm2Sjw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0003458 decreased circulating ketone body level "less than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Acacatm2Sjw/Acacatm2Sjw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou1f1dw/Pou1f1dw-J
Genetic Background: (DW/J x C3H/HeJ)F1

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Acacatm2Sjw/Acacatm2Sjw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Pou1f1dw/Pou1f1dw-J
Genetic Background: (DW/J x C3H/HeJ)F1

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acacatm2Sjw/Acacatm2Sjw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou1f1dw/Pou1f1dw-J
Genetic Background: (DW/J x C3H/HeJ)F1

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acacatm2Sjw/Acacatm2Sjw,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Smarcb1tm1Gvk/Smarcb1+
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0013245 abnormal lipid metabolism "any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
Show

Allelic Composition: Ctsdtm1.1Thre/Ctsdtm1.1Thre,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020532 Acaca / Q5SWU9 / acetyl-Coenzyme A carboxylase alpha / Q13085* / acetyl-CoA carboxylase alpha*  / -
 ENSMUSG00000040820 Hlcs / Q920N2 / holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) / P50747* / holocarboxylase synthetase*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr