ENSG00000078674


Homo sapiens

Features
Gene ID: ENSG00000078674
  
Biological name :PCM1
  
Synonyms : PCM1 / pericentriolar material 1 / Q15154
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p22
Gene start: 17922840
Gene end: 18029944
  
Corresponding Affymetrix probe sets: 202174_s_at (Human Genome U133 Plus 2.0 Array)   209996_x_at (Human Genome U133 Plus 2.0 Array)   209997_x_at (Human Genome U133 Plus 2.0 Array)   214118_x_at (Human Genome U133 Plus 2.0 Array)   214937_x_at (Human Genome U133 Plus 2.0 Array)   228905_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428123
Ensembl peptide - ENSP00000328332
Ensembl peptide - ENSP00000428131
Ensembl peptide - ENSP00000431099
Ensembl peptide - ENSP00000430521
Ensembl peptide - ENSP00000429941
Ensembl peptide - ENSP00000429054
Ensembl peptide - ENSP00000327077
NCBI entrez gene - 5108     See in Manteia.
OMIM - 600299
RefSeq - XM_017013508
RefSeq - XM_017013496
RefSeq - XM_017013497
RefSeq - XM_017013498
RefSeq - XM_017013499
RefSeq - XM_017013500
RefSeq - XM_017013501
RefSeq - XM_017013502
RefSeq - XM_017013503
RefSeq - XM_017013504
RefSeq - XM_017013505
RefSeq - XM_017013506
RefSeq - XM_017013507
RefSeq - NM_001315507
RefSeq - NM_001315508
RefSeq - NM_001352642
RefSeq - NM_001352659
RefSeq - NM_006197
RefSeq - XM_006716336
RefSeq - XM_006716340
RefSeq - XM_006716349
RefSeq - XM_011544528
RefSeq - XM_011544529
RefSeq - XM_011544530
RefSeq - XM_011544532
RefSeq - XM_011544533
RefSeq - XM_011544534
RefSeq - XM_011544535
RefSeq - XM_011544540
RefSeq - XM_017013472
RefSeq - XM_017013473
RefSeq - XM_017013474
RefSeq - XM_017013475
RefSeq - XM_017013476
RefSeq - XM_017013477
RefSeq - XM_017013478
RefSeq - XM_017013479
RefSeq - XM_017013480
RefSeq - XM_017013481
RefSeq - XM_017013482
RefSeq - XM_017013483
RefSeq - XM_017013484
RefSeq - XM_017013485
RefSeq - XM_017013486
RefSeq - XM_017013487
RefSeq - XM_017013488
RefSeq - XM_017013489
RefSeq - XM_017013490
RefSeq - XM_017013491
RefSeq - XM_017013492
RefSeq - XM_017013493
RefSeq - XM_017013494
RefSeq - XM_017013495
RefSeq Peptide - NP_001302437
RefSeq Peptide - NP_001339571
RefSeq Peptide - NP_001339588
RefSeq Peptide - NP_006188
RefSeq Peptide - NP_001302436
swissprot - Q15154
swissprot - A6NNN6
swissprot - E9PGW9
swissprot - E7EV93
swissprot - E7ETA6
swissprot - E5RGQ4
swissprot - H0YBA1
Ensembl - ENSG00000078674
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcm1ENSDARG00000062198Danio rerio
 PCM1ENSGALG00000013602Gallus gallus
 Pcm1ENSMUSG00000031592Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024138  Pericentriolar material 1 protein
 IPR031446  Pericentriolar material 1 protein, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0007098 centrosome cycle IMP
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0022027 interkinetic nuclear migration IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0031122 cytoplasmic microtubule organization IMP
 biological_processGO:0034453 microtubule anchoring IEA
 biological_processGO:0034454 microtubule anchoring at centrosome IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035735 intraciliary transport involved in cilium assembly IMP
 biological_processGO:0050768 negative regulation of neurogenesis IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0071539 protein localization to centrosome IEA
 biological_processGO:0090316 positive regulation of intracellular protein transport IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:1905515 non-motile cilium assembly IMP
 cellular_componentGO:0000242 pericentriolar material TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0034451 centriolar satellite IEA
 cellular_componentGO:0035869 ciliary transition zone IDA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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