ENSG00000080709


Homo sapiens

Features
Gene ID: ENSG00000080709
  
Biological name :KCNN2
  
Synonyms : KCNN2 / potassium calcium-activated channel subfamily N member 2 / Q9H2S1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q22.3
Gene start: 114360945
Gene end: 114496500
  
Corresponding Affymetrix probe sets: 220116_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427120
Ensembl peptide - ENSP00000421439
Ensembl peptide - ENSP00000483124
Ensembl peptide - ENSP00000487849
Ensembl peptide - ENSP00000264773
Ensembl peptide - ENSP00000421095
NCBI entrez gene - 3781     See in Manteia.
OMIM - 605879
RefSeq - XM_017009457
RefSeq - NM_001278204
RefSeq - NM_021614
RefSeq - NM_170775
RefSeq - XM_011543387
RefSeq - XM_011543389
RefSeq Peptide - NP_067627
RefSeq Peptide - NP_740721
RefSeq Peptide - NP_001265133
swissprot - D6RGY7
swissprot - Q9H2S1
swissprot - A0A0J9YW81
Ensembl - ENSG00000080709
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KCNN2ENSDARG00000014939Danio rerio
 KCNN2ENSGALG00000002539Gallus gallus
 Kcnn2ENSMUSG00000054477Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNN3 / Q9UGI6 / potassium calcium-activated channel subfamily N member 3ENSG0000014360373
KCNN1 / Q92952 / potassium calcium-activated channel subfamily N member 1ENSG0000010564266
KCNN4 / O15554 / potassium calcium-activated channel subfamily N member 4ENSG0000010478332


Protein motifs (from Interpro)
Interpro ID Name
 IPR004178  Calmodulin-binding domain
 IPR013099  Potassium channel domain
 IPR015449  Potassium channel, calcium-activated, SK
 IPR036122  SK, calmodulin-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport NAS
 biological_processGO:0071805 potassium ion transmembrane transport ISS
 biological_processGO:0098914 membrane repolarization during atrial cardiac muscle cell action potential ISS
 biological_processGO:1901379 regulation of potassium ion transmembrane transport IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0030018 Z disc ISS
 cellular_componentGO:0043025 neuronal cell body IBA
 cellular_componentGO:0043197 dendritic spine IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0015269 calcium-activated potassium channel activity IDA
 molecular_functionGO:0016286 small conductance calcium-activated potassium channel activity ISS
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0051393 alpha-actinin binding IPI


Pathways (from Reactome)
Pathway description
Ca2+ activated K+ channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000143603 KCNN3 / Q9UGI6 / potassium calcium-activated channel subfamily N member 3  / complex
 ENSG00000080709 KCNN2 / Q9H2S1 / potassium calcium-activated channel subfamily N member 2  / complex
 ENSG00000105642 KCNN1 / Q92952 / potassium calcium-activated channel subfamily N member 1  / complex






 

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