ENSG00000080802


Homo sapiens

Features
Gene ID: ENSG00000080802
  
Biological name :CNOT4
  
Synonyms : CCR4-NOT transcription complex subunit 4 / CNOT4 / O95628
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q33
Gene start: 135361795
Gene end: 135510127
  
Corresponding Affymetrix probe sets: 203291_at (Human Genome U133 Plus 2.0 Array)   210203_at (Human Genome U133 Plus 2.0 Array)   210204_s_at (Human Genome U133 Plus 2.0 Array)   210866_s_at (Human Genome U133 Plus 2.0 Array)   210867_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388491
Ensembl peptide - ENSP00000354673
Ensembl peptide - ENSP00000399108
Ensembl peptide - ENSP00000445508
Ensembl peptide - ENSP00000416532
Ensembl peptide - ENSP00000406777
Ensembl peptide - ENSP00000326731
Ensembl peptide - ENSP00000348485
NCBI entrez gene - 4850     See in Manteia.
OMIM - 604911
RefSeq - XM_017012235
RefSeq - NM_001008225
RefSeq - NM_001190847
RefSeq - NM_001190848
RefSeq - NM_001190849
RefSeq - NM_001190850
RefSeq - NM_013316
RefSeq Peptide - NP_037448
RefSeq Peptide - NP_001008226
RefSeq Peptide - NP_001177776
RefSeq Peptide - NP_001177777
RefSeq Peptide - NP_001177778
RefSeq Peptide - NP_001177779
swissprot - O95628
swissprot - A0A024R776
swissprot - A0A024R785
swissprot - A0A024R781
swissprot - A0A0A0MRD2
Ensembl - ENSG00000080802
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot4aENSDARG00000007045Danio rerio
 cnot4bENSDARG00000007639Danio rerio
 CNOT4ENSGALG00000011682Gallus gallus
 Cnot4ENSMUSG00000038784Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR000571  Zinc finger, CCCH-type
 IPR001841  Zinc finger, RING-type
 IPR003954  RNA recognition motif domain, eukaryote
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR034261  CNOT4, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0051865 protein autoubiquitination IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030014 CCR4-NOT complex IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr