ENSMUSG00000038784


Mus musculus

Features
Gene ID: ENSMUSG00000038784
  
Biological name :Cnot4
  
Synonyms : CCR4-NOT transcription complex subunit 4 / Cnot4 / Q8BT14
  
Possible biological names infered from orthology : O95628
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B1
Gene start: 35022065
Gene end: 35133724
  
Corresponding Affymetrix probe sets: 10543904 (MoGene1.0st)   1420999_at (Mouse Genome 430 2.0 Array)   1421000_at (Mouse Genome 430 2.0 Array)   1436645_a_at (Mouse Genome 430 2.0 Array)   1437586_at (Mouse Genome 430 2.0 Array)   1450083_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044137
Ensembl peptide - ENSMUSP00000110645
Ensembl peptide - ENSMUSP00000144352
Ensembl peptide - ENSMUSP00000144409
Ensembl peptide - ENSMUSP00000110640
NCBI entrez gene - 53621     See in Manteia.
MGI - MGI:1859026
RefSeq - XM_011241408
RefSeq - NM_001164411
RefSeq - NM_001164412
RefSeq - NM_001164413
RefSeq - NM_001164414
RefSeq - NM_016877
RefSeq - XM_011241407
RefSeq Peptide - NP_001157883
RefSeq Peptide - NP_001157884
RefSeq Peptide - NP_001157885
RefSeq Peptide - NP_001157886
RefSeq Peptide - NP_058573
swissprot - A0A0R4J1K1
swissprot - Q05BG1
swissprot - Q3TMD4
swissprot - Q8BT14
swissprot - E9QA19
Ensembl - ENSMUSG00000038784
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot4aENSDARG00000007045Danio rerio
 cnot4bENSDARG00000007639Danio rerio
 CNOT4ENSGALG00000011682Gallus gallus
 CNOT4ENSG00000080802Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR000571  Zinc finger, CCCH-type
 IPR001841  Zinc finger, RING-type
 IPR003954  RNA recognition motif domain, eukaryote
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR034261  CNOT4, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0051865 protein autoubiquitination ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030014 CCR4-NOT complex IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay

 MP:0012768 decreased KLRG1-positive NK cell number "decrease in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [MGI:Annie_Speak, PMID:19479342]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0013421 increased CD5-positive gamma-delta T cell number "increase in the number of CD5+ gamma-delta T cells" [IMPC:Saran]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr