ENSG00000086544


Homo sapiens

Features
Gene ID: ENSG00000086544
  
Biological name :ITPKC
  
Synonyms : inositol-trisphosphate 3-kinase C / ITPKC / Q96DU7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 40717103
Gene end: 40740860
  
Corresponding Affymetrix probe sets: 213076_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472655
Ensembl peptide - ENSP00000263370
NCBI entrez gene - 80271     See in Manteia.
OMIM - 606476
RefSeq - XM_017027324
RefSeq - NM_025194
RefSeq Peptide - NP_079470
swissprot - A0A024R0N8
swissprot - Q96DU7
swissprot - M0R2L7
Ensembl - ENSG00000086544
  
Related genetic diseases (OMIM): 611775 - {Kawasaki disease, susceptibility to}, 611775
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itpkcaENSDARG00000002994Danio rerio
 itpkcbENSDARG00000067741Danio rerio
 ItpkcENSMUSG00000003752Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITPKB / P27987 / inositol-trisphosphate 3-kinase BENSG0000014377234
ITPKA / P23677 / inositol-trisphosphate 3-kinase AENSG0000013782529


Protein motifs (from Interpro)
Interpro ID Name
 IPR005522  Inositol polyphosphate kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032958 inositol phosphate biosynthetic process IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity TAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex






 

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