ENSG00000137825


Homo sapiens

Features
Gene ID: ENSG00000137825
  
Biological name :ITPKA
  
Synonyms : inositol-trisphosphate 3-kinase A / ITPKA / P23677
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q15.1
Gene start: 41493393
Gene end: 41503551
  
Corresponding Affymetrix probe sets: 205874_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000260386
Ensembl peptide - ENSP00000396560
NCBI entrez gene - 3706     See in Manteia.
OMIM - 147521
RefSeq - NM_002220
RefSeq - XM_011521522
RefSeq Peptide - NP_002211
swissprot - C9JC74
swissprot - P23677
Ensembl - ENSG00000137825
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itpkaENSDARG00000042856Danio rerio
 ITPKAENSGALG00000008603Gallus gallus
 ItpkaENSMUSG00000027296Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITPKB / P27987 / inositol-trisphosphate 3-kinase BENSG0000014377250
ITPKC / Q96DU7 / inositol-trisphosphate 3-kinase CENSG0000008654443


Protein motifs (from Interpro)
Interpro ID Name
 IPR005522  Inositol polyphosphate kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006020 inositol metabolic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0032958 inositol phosphate biosynthetic process IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0097062 dendritic spine maintenance IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex






 

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