ENSG00000143772


Homo sapiens

Features
Gene ID: ENSG00000143772
  
Biological name :ITPKB
  
Synonyms : inositol-trisphosphate 3-kinase B / ITPKB / P27987
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q42.12
Gene start: 226631690
Gene end: 226739323
  
Corresponding Affymetrix probe sets: 1554306_at (Human Genome U133 Plus 2.0 Array)   203723_at (Human Genome U133 Plus 2.0 Array)   232499_at (Human Genome U133 Plus 2.0 Array)   232526_at (Human Genome U133 Plus 2.0 Array)   235213_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411152
Ensembl peptide - ENSP00000272117
Ensembl peptide - ENSP00000355748
NCBI entrez gene - 3707     See in Manteia.
OMIM - 147522
RefSeq - NM_002221
RefSeq - XM_005273120
RefSeq Peptide - NP_002212
swissprot - P27987
Ensembl - ENSG00000143772
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itpkbENSDARG00000010059Danio rerio
 ITPKBENSGALG00000009068Gallus gallus
 ItpkbENSMUSG00000038855Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITPKC / Q96DU7 / inositol-trisphosphate 3-kinase CENSG0000008654424
ITPKA / P23677 / inositol-trisphosphate 3-kinase AENSG0000013782524


Protein motifs (from Interpro)
Interpro ID Name
 IPR005522  Inositol polyphosphate kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0002262 myeloid cell homeostasis IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0032957 inositol trisphosphate metabolic process IDA
 biological_processGO:0032958 inositol phosphate biosynthetic process IEA
 biological_processGO:0033030 negative regulation of neutrophil apoptotic process IEA
 biological_processGO:0035726 common myeloid progenitor cell proliferation IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0045059 positive thymic T cell selection IEA
 biological_processGO:0045061 thymic T cell selection IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IEA
 biological_processGO:0071277 cellular response to calcium ion IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex






 

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