ENSMUSG00000038855


Mus musculus

Features
Gene ID: ENSMUSG00000038855
  
Biological name :Itpkb
  
Synonyms : inositol-trisphosphate 3-kinase B / Itpkb
  
Possible biological names infered from orthology : P27987
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H4
Gene start: 180330485
Gene end: 180424802
  
Corresponding Affymetrix probe sets: 10352234 (MoGene1.0st)   1435272_at (Mouse Genome 430 2.0 Array)   1441058_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069851
NCBI entrez gene - 320404     See in Manteia.
MGI - MGI:109235
RefSeq - NM_001081175
RefSeq - XM_006496903
RefSeq Peptide - NP_001074644
swissprot - B2RXC2
Ensembl - ENSMUSG00000038855
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itpkbENSDARG00000010059Danio rerio
 ITPKBENSGALG00000009068Gallus gallus
 ITPKBENSG00000143772Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itpka / Q8R071 / Inositol-trisphosphate 3-kinase A / P23677*ENSMUSG0000002729625
Itpkc / Q7TS72 / Inositol-trisphosphate 3-kinase C / Q96DU7*ENSMUSG0000000375225


Protein motifs (from Interpro)
Interpro ID Name
 IPR005522  Inositol polyphosphate kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0002262 myeloid cell homeostasis IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0032957 inositol trisphosphate metabolic process IEA
 biological_processGO:0032958 inositol phosphate biosynthetic process IEA
 biological_processGO:0033030 negative regulation of neutrophil apoptotic process IMP
 biological_processGO:0035726 common myeloid progenitor cell proliferation IMP
 biological_processGO:0045059 positive thymic T cell selection IMP
 biological_processGO:0045061 thymic T cell selection IMP
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IMP
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IMP
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IMP
 biological_processGO:0071277 cellular response to calcium ion IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: ItpkbT-less/ItpkbT-less
Genetic Background: C57BL/6-ItpkbT-less

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppef1tm1Nat/Y,Ppef2tm1Nat/Ppef2tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009511 distended stomach "an expansion in the volume of the sac-like structure of the digestive canal between the esophagus and the small intestine, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013587 absent thymus medulla "lacking the inner area of thymus lobules" [MGI:Anna]
Show

Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex






 

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