ENSMUSG00000003752


Mus musculus

Features
Gene ID: ENSMUSG00000003752
  
Biological name :Itpkc
  
Synonyms : Inositol-trisphosphate 3-kinase C / Itpkc / Q7TS72
  
Possible biological names infered from orthology : Q96DU7
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 27207172
Gene end: 27228661
  
Corresponding Affymetrix probe sets: 10561204 (MoGene1.0st)   1454755_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003850
NCBI entrez gene - 233011     See in Manteia.
MGI - MGI:2442554
RefSeq - NM_181593
RefSeq Peptide - NP_853624
swissprot - Q7TS72
Ensembl - ENSMUSG00000003752
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itpkcaENSDARG00000002994Danio rerio
 itpkcbENSDARG00000067741Danio rerio
 ITPKCENSG00000086544Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itpkb / inositol-trisphosphate 3-kinase B / P27987*ENSMUSG0000003885535
Itpka / Q8R071 / Inositol-trisphosphate 3-kinase A / P23677*ENSMUSG0000002729630


Protein motifs (from Interpro)
Interpro ID Name
 IPR005522  Inositol polyphosphate kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032958 inositol phosphate biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Blmtm3Brd/Blmtm3Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex






 

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