ENSMUSG00000027296


Mus musculus

Features
Gene ID: ENSMUSG00000027296
  
Biological name :Itpka
  
Synonyms : Inositol-trisphosphate 3-kinase A / Itpka / Q8R071
  
Possible biological names infered from orthology : P23677
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 119742337
Gene end: 119751263
  
Corresponding Affymetrix probe sets: 10475019 (MoGene1.0st)   1424037_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028758
NCBI entrez gene - 228550     See in Manteia.
MGI - MGI:1333822
RefSeq - NM_146125
RefSeq Peptide - NP_666237
swissprot - Q8R071
Ensembl - ENSMUSG00000027296
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itpkaENSDARG00000042856Danio rerio
 ITPKAENSGALG00000008603Gallus gallus
 ITPKAENSG00000137825Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itpkb / inositol-trisphosphate 3-kinase B / P27987*ENSMUSG0000003885551
Itpkc / Q7TS72 / Inositol-trisphosphate 3-kinase C / Q96DU7*ENSMUSG0000000375245


Protein motifs (from Interpro)
Interpro ID Name
 IPR005522  Inositol polyphosphate kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006020 inositol metabolic process IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0032958 inositol phosphate biosynthetic process IEA
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0097062 dendritic spine maintenance IEA
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Rettm2.1Cos/Ret+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex






 

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