ENSG00000088038


Homo sapiens

Features
Gene ID: ENSG00000088038
  
Biological name :CNOT3
  
Synonyms : CCR4-NOT transcription complex subunit 3 / CNOT3 / O75175
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.42
Gene start: 54137717
Gene end: 54155708
  
Corresponding Affymetrix probe sets: 203239_s_at (Human Genome U133 Plus 2.0 Array)   211141_s_at (Human Genome U133 Plus 2.0 Array)   229143_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000494008
Ensembl peptide - ENSP00000496602
Ensembl peptide - ENSP00000496534
Ensembl peptide - ENSP00000495445
Ensembl peptide - ENSP00000495366
Ensembl peptide - ENSP00000221232
Ensembl peptide - ENSP00000351159
Ensembl peptide - ENSP00000398463
Ensembl peptide - ENSP00000401703
Ensembl peptide - ENSP00000411587
Ensembl peptide - ENSP00000420064
Ensembl peptide - ENSP00000483360
NCBI entrez gene - 4849     See in Manteia.
OMIM - 604910
RefSeq - XM_011526993
RefSeq - NM_014516
RefSeq - XM_005278279
RefSeq - XM_005278280
RefSeq - XM_005278281
RefSeq - XM_005278282
RefSeq - XM_011526992
RefSeq Peptide - NP_055331
swissprot - O75175
swissprot - A0A024R4R3
swissprot - A0A087X0F9
swissprot - H0Y5X7
swissprot - H7C148
swissprot - H7C3F5
swissprot - B7Z6J7
swissprot - H7C5J4
Ensembl - ENSG00000088038
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot3aENSDARG00000007135Danio rerio
 cnot3bENSDARG00000019842Danio rerio
 Cnot3ENSMUSG00000035632Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007207  CCR4-Not complex component, Not N-terminal domain
 IPR007282  NOT2/NOT3/NOT5
 IPR012270  CCR4-NOT complex, subunit 3/ 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0001829 trophectodermal cell differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0017148 negative regulation of translation IBA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:2000036 regulation of stem cell population maintenance IMP
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030014 CCR4-NOT complex IDA
 cellular_componentGO:0030015 CCR4-NOT core complex IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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