Manteia - Molecule gene

ENSMUSG00000035632

Mus musculus

Features

Gene ID:	ENSMUSG00000035632

Biological name :	Cnot3

Synonyms :	CCR4-NOT transcription complex subunit 3 / Cnot3 / Q8K0V4

Possible biological names infered from orthology :	O75175

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	A1
Gene start:	3645268
Gene end:	3661109

Corresponding Affymetrix probe sets:	10549569 (MoGene1.0st) 1435965_at (Mouse Genome 430 2.0 Array) 1441465_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000117297 Ensembl peptide - ENSMUSP00000124810 Ensembl peptide - ENSMUSP00000145641 Ensembl peptide - ENSMUSP00000039098 Ensembl peptide - ENSMUSP00000118822 NCBI entrez gene - 232791 See in Manteia. MGI - MGI:2385261 RefSeq - XM_017322146 RefSeq - XM_006539755 RefSeq - XM_006539756 RefSeq - XM_006539757 RefSeq - XM_011250500 RefSeq - XM_011250501 RefSeq - XM_017322145 RefSeq - NM_146176 RefSeq - XM_006539752 RefSeq - XM_006539753 RefSeq Peptide - NP_666288 swissprot - F6WUZ2 swissprot - F6YBV1 swissprot - F6UAW9 swissprot - A0A0U1RNN8 swissprot - Q8K0V4 Ensembl - ENSMUSG00000035632

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
cnot3a	ENSDARG00000007135	Danio rerio
cnot3b	ENSDARG00000019842	Danio rerio
CNOT3	ENSG00000088038	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR007207	CCR4-Not complex component, Not N-terminal domain
IPR007282	NOT2/NOT3/NOT5
IPR012270	CCR4-NOT complex, subunit 3/ 5

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA
biological_process	GO:0001829	trophectodermal cell differentiation	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006417	regulation of translation	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0017148	negative regulation of translation	IBA
biological_process	GO:0031047	gene silencing by RNA	IEA
biological_process	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	ISS
biological_process	GO:2000036	regulation of stem cell population maintenance	IEA
cellular_component	GO:0000932	P-body	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0030014	CCR4-NOT complex	IEA
cellular_component	GO:0030015	CCR4-NOT core complex	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0000066	osteoporosis	"reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Adora2b^tm1Msit/Adora2b^tm1Msit,Tg(Sftpc-cre)1Blh/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0000601	small liver	"reduced size of the liver" [J:23170]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N Allelic Composition: Cnot3^tm1.1Tya/Cnot3⁺,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001625	cardiac hypertrophy	"an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001636	irregular heartbeat	"uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]	Show Allelic Composition: Adora2b^tm1Msit/Adora2b^tm1Msit,Tg(Sftpc-cre)1Blh/0 Genetic Background: involves: C57BL/6 * DBA/2
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Adora2b^tm1Msit/Adora2b^tm1Msit,Tg(Sftpc-cre)1Blh/0 Genetic Background: involves: C57BL/6 * DBA/2 Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB Allelic Composition: Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * FVB/N Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ Genetic Background:* involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N Allelic Composition: Atg5^tm1Myok/Atg5^tm1Myok,Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0002310	resistance to fatty liver development	"less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0002718	abnormal inner cell mass	"malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB Allelic Composition: Atg5^tm1Myok/Atg5^tm1Myok,Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N Allelic Composition: Cnot3^tm1.1Tya/Cnot3⁺,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003233	prolonged QT interval	"increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB Allelic Composition: Atg5^tm1Myok/Atg5^tm1Myok,Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB
MP:0003824	decreased left ventricular developed pressure	"decrease in the difference between left ventricular systolic and diastolic pressures" [RGD:Rat Genome Database submission]	Show Allelic Composition: Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004567	decreased myocardial fiber number	"decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0004984	increased osteoclast cell number	"greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0004992	increased bone resorption	"greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ Genetic Background:* involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf^{Tg(Myh6-cre/Esr1)1Jmk} Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N Allelic Composition: Atg5^tm1Myok/Atg5^tm1Myok,Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB
MP:0005289	increased oxygen consumption	"greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N Allelic Composition: Cnot3^tm1.1Tya/Cnot3⁺,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N Allelic Composition: Cnot3^tm1.1Tya/Cnot3⁺,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005330	cardiomyopathy	"diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]	Show Allelic Composition: Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0005459	decreased percent body fat	"less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0005598	decreased ventricle muscle contractility	"reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0008260	abnormal autophagy	"abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB Allelic Composition: Atg5^tm1Myok/Atg5^tm1Myok,Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0009133	decreased white fat cell size	"reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0009136	decreased brown fat cell size	"reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0009346	decreased cancellous bone thickness	"thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0009703	decreased birth body size	"reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0010379	decreased respiratory quotient	"reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cnot3^tm1.1Tya/Cnot3⁺,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0010579	increased heart left ventricle size	"greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010632	cardiac muscle necrosis	"pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0010869	decreased bone trabecula number	"decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0010873	decreased trabecular bone mass	"reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Cnot3^tm1.1Tya/Cnot3⁺,Lep^ob/Lep^ob Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011093	complete embryonic lethality at implantation	"death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]	Show Allelic Composition: Nox4^tm1.1Hwsc/Nox4^tm1.1Hwsc Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0013278	decreased fasted circulating glucose level	"reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N
MP:0014143	decreased body fat mass	"decreased physical bulk or volume of fat in the whole body" [MGI:csmith]	Show Allelic Composition: Mst1r^{tm2(Mst1r)Sew}/Mst1r^{tm2(Mst1r)Sew} Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr