ENSG00000088930


Homo sapiens

Features
Gene ID: ENSG00000088930
  
Biological name :XRN2
  
Synonyms : 5-3 exoribonuclease 2 / Q9H0D6 / XRN2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p11.22
Gene start: 21303304
Gene end: 21389827
  
Corresponding Affymetrix probe sets: 223002_s_at (Human Genome U133 Plus 2.0 Array)   233878_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366396
NCBI entrez gene - 22803     See in Manteia.
OMIM - 608851
RefSeq - XM_017027723
RefSeq - NM_001317960
RefSeq - NM_012255
RefSeq Peptide - NP_036387
RefSeq Peptide - NP_001304889
swissprot - Q9H0D6
Ensembl - ENSG00000088930
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xrn2ENSDARG00000101900Danio rerio
 XRN2ENSGALG00000008372Gallus gallus
 Xrn2ENSMUSG00000027433Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004859  Putative 5-3 exonuclease
 IPR017151  5"-3" exoribonuclease type 2
 IPR027073  5"-3" exoribonuclease


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000738 DNA catabolic process, exonucleolytic IDA
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006353 DNA-templated transcription, termination IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006396 RNA processing TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006401 RNA catabolic process TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016070 RNA metabolic process IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016235 aggresome IDA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity EXP
 molecular_functionGO:0001147 transcription termination site sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004518 nuclease activity TAS
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004534 5"-3" exoribonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008409 5"-3" exonuclease activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Association of TriC/CCT with target proteins during biosynthesis
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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