ENSG00000092871


Homo sapiens

Features
Gene ID: ENSG00000092871
  
Biological name :RFFL
  
Synonyms : Q8WZ73 / RFFL / ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q12
Gene start: 35005990
Gene end: 35089319
  
Corresponding Affymetrix probe sets: 1552649_a_at (Human Genome U133 Plus 2.0 Array)   1552651_a_at (Human Genome U133 Plus 2.0 Array)   1562603_at (Human Genome U133 Plus 2.0 Array)   1566171_at (Human Genome U133 Plus 2.0 Array)   228980_at (Human Genome U133 Plus 2.0 Array)   237919_at (Human Genome U133 Plus 2.0 Array)   242155_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462656
Ensembl peptide - ENSP00000464000
Ensembl peptide - ENSP00000463035
Ensembl peptide - ENSP00000326170
Ensembl peptide - ENSP00000378096
Ensembl peptide - ENSP00000389832
Ensembl peptide - ENSP00000395090
Ensembl peptide - ENSP00000408513
Ensembl peptide - ENSP00000412322
Ensembl peptide - ENSP00000462499
NCBI entrez gene - 117584     See in Manteia.
OMIM - 609735
RefSeq - NM_001017368
RefSeq Peptide - NP_001017368
swissprot - J3QR17
swissprot - C9JE27
swissprot - Q8WZ73
swissprot - J3KSI3
swissprot - J3KSU7
Ensembl - ENSG00000092871
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfflENSDARG00000042833Danio rerio
 zgc:171740ENSDARG00000056244Danio rerio
 RFFLENSGALG00000002225Gallus gallus
 RfflENSMUSG00000020696Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RNF34 / Q969K3 / ring finger protein 34ENSG0000017063344
AC004223.3ENSG0000026761831


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010762 regulation of fibroblast migration ISS
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032006 regulation of TOR signaling IC
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:1901797 negative regulation of signal transduction by p53 class mediator IMP
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IMP
 cellular_componentGO:0002947 tumor necrosis factor receptor superfamily complex IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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