ENSG00000170633


Homo sapiens

Features
Gene ID: ENSG00000170633
  
Biological name :RNF34
  
Synonyms : Q969K3 / ring finger protein 34 / RNF34
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.31
Gene start: 121400041
Gene end: 121430623
  
Corresponding Affymetrix probe sets: 219035_s_at (Human Genome U133 Plus 2.0 Array)   229855_at (Human Genome U133 Plus 2.0 Array)   236288_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451724
Ensembl peptide - ENSP00000452096
Ensembl peptide - ENSP00000452200
Ensembl peptide - ENSP00000452321
Ensembl peptide - ENSP00000477987
Ensembl peptide - ENSP00000355137
Ensembl peptide - ENSP00000376257
Ensembl peptide - ENSP00000376258
NCBI entrez gene - 80196     See in Manteia.
OMIM - 608299
RefSeq - NM_194271
RefSeq - NM_001256858
RefSeq - NM_025126
RefSeq Peptide - NP_919247
RefSeq Peptide - NP_079402
RefSeq Peptide - NP_001243787
swissprot - Q969K3
swissprot - A0A087WTM5
swissprot - G3V4D1
swissprot - G3V504
swissprot - G3V566
swissprot - G3V5F1
swissprot - H7BYJ1
Ensembl - ENSG00000170633
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf34aENSDARG00000038300Danio rerio
 rnf34bENSDARG00000054036Danio rerio
 RNF34ENSGALG00000004190Gallus gallus
 Rnf34ENSMUSG00000029474Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RFFL / Q8WZ73 / ring finger and FYVE like domain containing E3 ubiquitin protein ligaseENSG0000009287143
AC004223.3ENSG0000026761823


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0070417 cellular response to cold IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IMP
 biological_processGO:1901797 negative regulation of signal transduction by p53 class mediator IMP
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:2000374 regulation of oxygen metabolic process IEA
 biological_processGO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:1901981 phosphatidylinositol phosphate binding IDA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Degradation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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