ENSMUSG00000020696


Mus musculus

Features
Gene ID: ENSMUSG00000020696
  
Biological name :Rffl
  
Synonyms : E3 ubiquitin-protein ligase rififylin / Q6ZQM0 / Rffl
  
Possible biological names infered from orthology : AC004223.3 / Q8WZ73 / ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 82802449
Gene end: 82871210
  
Corresponding Affymetrix probe sets: 10389087 (MoGene1.0st)   1431748_a_at (Mouse Genome 430 2.0 Array)   1434432_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115846
Ensembl peptide - ENSMUSP00000099507
Ensembl peptide - ENSMUSP00000103808
Ensembl peptide - ENSMUSP00000021036
Ensembl peptide - ENSMUSP00000071150
Ensembl peptide - ENSMUSP00000074108
Ensembl peptide - ENSMUSP00000091510
NCBI entrez gene - 67338     See in Manteia.
MGI - MGI:1914588
RefSeq - XM_017314715
RefSeq - NM_001007465
RefSeq - NM_001164569
RefSeq - NM_001164570
RefSeq - NM_001164571
RefSeq - NM_026097
RefSeq - XM_006533987
RefSeq - XM_006533988
RefSeq - XM_006533989
RefSeq - XM_006533990
RefSeq Peptide - NP_080373
RefSeq Peptide - NP_001007466
RefSeq Peptide - NP_001158041
RefSeq Peptide - NP_001158042
RefSeq Peptide - NP_001158043
swissprot - B1AT06
swissprot - Q148A8
swissprot - Q3UCG9
swissprot - Q3UD78
swissprot - Q6ZQM0
Ensembl - ENSMUSG00000020696
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfflENSDARG00000042833Danio rerio
 zgc:171740ENSDARG00000056244Danio rerio
 RFFLENSGALG00000002225Gallus gallus
 AC004223.3ENSG00000267618Homo sapiens
 RFFLENSG00000092871Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rnf34 / Q99KR6 / E3 ubiquitin-protein ligase RNF34 / Q969K3* / ring finger protein 34*ENSMUSG0000002947440


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0006886 intracellular protein transport IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010762 regulation of fibroblast migration IMP
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway ISS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0070936 protein K48-linked ubiquitination ISS
 biological_processGO:1901797 negative regulation of signal transduction by p53 class mediator ISS
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
 biological_processGO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO
 cellular_componentGO:0002947 tumor necrosis factor receptor superfamily complex ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0010008 endosome membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0002039 p53 binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISS


Pathways (from Reactome)
Pathway description
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lcattm1Hgc/Lcattm1Hgc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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