ENSG00000100994


Homo sapiens

Features
Gene ID: ENSG00000100994
  
Biological name :PYGB
  
Synonyms : glycogen phosphorylase B / P11216 / PYGB
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p11.21
Gene start: 25248069
Gene end: 25298014
  
Corresponding Affymetrix probe sets: 201481_s_at (Human Genome U133 Plus 2.0 Array)   243238_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000216962
Ensembl peptide - ENSP00000395451
NCBI entrez gene - 5834     See in Manteia.
OMIM - 138550
RefSeq - NM_002862
RefSeq Peptide - NP_002853
swissprot - P11216
swissprot - H0Y4Z6
Ensembl - ENSG00000100994
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pygbENSDARG00000002021Danio rerio
 PYGBENSGALG00000008508Gallus gallus
 PygbENSMUSG00000033059Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PYGM / P11217 / glycogen phosphorylase, muscle associatedENSG0000006897683
PYGL / P06737 / glycogen phosphorylase LENSG0000010050481


Protein motifs (from Interpro)
Interpro ID Name
 IPR000811  Glycosyl transferase, family 35
 IPR011833  Glycogen/starch/alpha-glucan phosphorylase
 IPR035090  Phosphorylase pyridoxal-phosphate attachment site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0005980 glycogen catabolic process NAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004645 phosphorylase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008184 glycogen phosphorylase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IBA
 molecular_functionGO:0102250 linear malto-oligosaccharide phosphorylase activity IEA
 molecular_functionGO:0102499 SHG alpha-glucan phosphorylase activity IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Glycogen breakdown (glycogenolysis)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100994 PYGB / P11216 / glycogen phosphorylase B  / complex
 ENSG00000164776 PHKG1 / Q16816 / phosphorylase kinase catalytic subunit gamma 1  / reaction
 ENSG00000102893 PHKB / Q93100 / phosphorylase kinase regulatory subunit beta  / reaction
 ENSG00000067177 PHKA1 / P46020 / phosphorylase kinase regulatory subunit alpha 1  / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction






 

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