ENSG00000105662


Homo sapiens

Features
Gene ID: ENSG00000105662
  
Biological name :CRTC1
  
Synonyms : CREB regulated transcription coactivator 1 / CRTC1 / Q6UUV9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.11
Gene start: 18683677
Gene end: 18782333
  
Corresponding Affymetrix probe sets: 207159_x_at (Human Genome U133 Plus 2.0 Array)   213091_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000323332
Ensembl peptide - ENSP00000345001
Ensembl peptide - ENSP00000468893
Ensembl peptide - ENSP00000469285
NCBI entrez gene - 23373     See in Manteia.
OMIM - 607536
RefSeq - XM_017026537
RefSeq - XM_005259835
RefSeq - XM_005259836
RefSeq - XM_006722710
RefSeq - XM_011527842
RefSeq - XM_017026536
RefSeq - NM_001098482
RefSeq - NM_015321
RefSeq - XM_005259833
RefSeq - XM_005259834
RefSeq Peptide - NP_001091952
RefSeq Peptide - NP_056136
swissprot - M0QXN6
swissprot - Q6UUV9
swissprot - M0QX46
Ensembl - ENSG00000105662
  
Related genetic diseases (OMIM): 607536 - Mucoepidermoid salivary gland carcinoma
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crtc1aENSDARG00000076068Danio rerio
 crtc1bENSDARG00000076076Danio rerio
 CRTC1ENSGALG00000003304Gallus gallus
 Crtc1ENSMUSG00000003575Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CRTC2 / Q53ET0 / CREB regulated transcription coactivator 2ENSG0000016074138
CRTC3 / Q6UUV7 / CREB regulated transcription coactivator 3ENSG0000014057732


Protein motifs (from Interpro)
Interpro ID Name
 IPR024783  Transducer of regulated CREB activity, N-terminal
 IPR024784  Transducer of regulated CREB activity, middle domain
 IPR024785  Transducer of regulated CREB activity, C-terminal
 IPR024786  CREB-regulated transcription coactivator


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0032793 positive regulation of CREB transcription factor activity IEA
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0097009 energy homeostasis IEA
 biological_processGO:1900006 positive regulation of dendrite development IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IEA
 biological_processGO:1902631 negative regulation of membrane hyperpolarization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008140 cAMP response element binding protein binding IDA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / complex






 

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