ENSMUSG00000003575


Mus musculus

Features
Gene ID: ENSMUSG00000003575
  
Biological name :Crtc1
  
Synonyms : CREB-regulated transcription coactivator 1 / Crtc1 / Q68ED7
  
Possible biological names infered from orthology : Q6UUV9
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 70382355
Gene end: 70439579
  
Corresponding Affymetrix probe sets: 10579262 (MoGene1.0st)   1434476_at (Mouse Genome 430 2.0 Array)   1446533_at (Mouse Genome 430 2.0 Array)   1447538_at (Mouse Genome 430 2.0 Array)   1458443_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075916
NCBI entrez gene - 382056     See in Manteia.
MGI - MGI:2142523
RefSeq - XM_011242313
RefSeq - NM_001004062
RefSeq - XM_011242311
RefSeq - XM_011242312
RefSeq - XM_006509699
RefSeq - XM_006509700
RefSeq - XM_006509704
RefSeq - XM_011242309
RefSeq - XM_011242310
RefSeq Peptide - NP_001004062
swissprot - Q68ED7
Ensembl - ENSMUSG00000003575
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crtc1aENSDARG00000076068Danio rerio
 crtc1bENSDARG00000076076Danio rerio
 CRTC1ENSGALG00000003304Gallus gallus
 CRTC1ENSG00000105662Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crtc2 / Q3U182 / CREB-regulated transcription coactivator 2 / Q53ET0*ENSMUSG0000002793639
Crtc3 / Q91X84 / CREB-regulated transcription coactivator 3 / Q6UUV7*ENSMUSG0000003052730


Protein motifs (from Interpro)
Interpro ID Name
 IPR024783  Transducer of regulated CREB activity, N-terminal
 IPR024784  Transducer of regulated CREB activity, middle domain
 IPR024785  Transducer of regulated CREB activity, C-terminal
 IPR024786  CREB-regulated transcription coactivator


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007613 memory IMP
 biological_processGO:0032793 positive regulation of CREB transcription factor activity IMP
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0097009 energy homeostasis IMP
 biological_processGO:1900006 positive regulation of dendrite development IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IEA
 biological_processGO:1902631 negative regulation of membrane hyperpolarization IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0008140 cAMP response element binding protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001354 increased aggression towards males "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001356 increased aggression towards females "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward female mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0009081 thin uterus "reduced thickness or depth of the female muscular organ of gestation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Cyp1a1-cre)1Dwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009710 anhedonia "inability to experience pleasure in response to normally pleasurable stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Kif20bmagoo/Kif20bmagoo
Genetic Background: involves: BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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