ENSMUSG00000027936


Mus musculus

Features
Gene ID: ENSMUSG00000027936
  
Biological name :Crtc2
  
Synonyms : CREB-regulated transcription coactivator 2 / Crtc2 / Q3U182
  
Possible biological names infered from orthology : Q53ET0
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 90254163
Gene end: 90264125
  
Corresponding Affymetrix probe sets: 10493711 (MoGene1.0st)   1424660_s_at (Mouse Genome 430 2.0 Array)   1429373_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029545
Ensembl peptide - ENSMUSP00000139194
NCBI entrez gene - 74343     See in Manteia.
MGI - MGI:1921593
RefSeq - XM_006502154
RefSeq - NM_028881
RefSeq - XM_006502152
RefSeq - XM_006502153
RefSeq Peptide - NP_083157
swissprot - Q3U182
swissprot - V9GXK6
Ensembl - ENSMUSG00000027936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crtc2ENSDARG00000074910Danio rerio
 CRTC2ENSG00000160741Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crtc1 / Q68ED7 / CREB-regulated transcription coactivator 1 / Q6UUV9*ENSMUSG0000000357536
Crtc3 / Q91X84 / CREB-regulated transcription coactivator 3 / Q6UUV7*ENSMUSG0000003052732


Protein motifs (from Interpro)
Interpro ID Name
 IPR024783  Transducer of regulated CREB activity, N-terminal
 IPR024784  Transducer of regulated CREB activity, middle domain
 IPR024785  Transducer of regulated CREB activity, C-terminal
 IPR024786  CREB-regulated transcription coactivator


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006094 gluconeogenesis IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032793 positive regulation of CREB transcription factor activity IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043970 histone H3-K9 acetylation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:1901998 toxin transport IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008140 cAMP response element binding protein binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1em3Psv/Dicer1em3Psv
Genetic Background: involves: C57BL/6NCrl

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Dicer1em3Psv/Dicer1em3Psv
Genetic Background: involves: C57BL/6NCrl

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Dicer1em3Psv/Dicer1em3Psv
Genetic Background: involves: C57BL/6NCrl

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1em3Psv/Dicer1em3Psv
Genetic Background: involves: C57BL/6NCrl

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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