ENSMUSG00000030527


Mus musculus

Features
Gene ID: ENSMUSG00000030527
  
Biological name :Crtc3
  
Synonyms : CREB-regulated transcription coactivator 3 / Crtc3 / Q91X84
  
Possible biological names infered from orthology : Q6UUV7
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D3
Gene start: 80586627
Gene end: 80688877
  
Corresponding Affymetrix probe sets: 10565002 (MoGene1.0st)   1436379_at (Mouse Genome 430 2.0 Array)   1451778_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113540
Ensembl peptide - ENSMUSP00000117255
Ensembl peptide - ENSMUSP00000123107
NCBI entrez gene - 70461     See in Manteia.
MGI - MGI:1917711
RefSeq - XM_006541195
RefSeq - XM_006541196
RefSeq - NM_173863
RefSeq Peptide - NP_776288
swissprot - Q91X84
swissprot - F6Y626
swissprot - F6UMS9
Ensembl - ENSMUSG00000030527
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crtc3ENSDARG00000052114Danio rerio
 CRTC3ENSG00000140577Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crtc2 / Q3U182 / CREB-regulated transcription coactivator 2 / Q53ET0*ENSMUSG0000002793636
Crtc1 / Q68ED7 / CREB-regulated transcription coactivator 1 / Q6UUV9*ENSMUSG0000000357531


Protein motifs (from Interpro)
Interpro ID Name
 IPR024783  Transducer of regulated CREB activity, N-terminal
 IPR024784  Transducer of regulated CREB activity, middle domain
 IPR024785  Transducer of regulated CREB activity, C-terminal
 IPR024786  CREB-regulated transcription coactivator


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032793 positive regulation of CREB transcription factor activity IEA
 biological_processGO:0042116 macrophage activation IEA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050995 negative regulation of lipid catabolic process IMP
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0097009 energy homeostasis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0008140 cAMP response element binding protein binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Crtc3tm1Mmy/Crtc3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009127 increased brown fat cell number "increase in the number of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0010102 increased caudal vertebrae number "increased number of the bony segments of the coccyx or tail" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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