ENSG00000109189


Homo sapiens

Features
Gene ID: ENSG00000109189
  
Biological name :USP46
  
Synonyms : P62068 / ubiquitin specific peptidase 46 / USP46
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q12
Gene start: 52590972
Gene end: 52659335
  
Corresponding Affymetrix probe sets: 203869_at (Human Genome U133 Plus 2.0 Array)   203870_at (Human Genome U133 Plus 2.0 Array)   219943_s_at (Human Genome U133 Plus 2.0 Array)   222941_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423244
Ensembl peptide - ENSP00000422018
Ensembl peptide - ENSP00000425806
Ensembl peptide - ENSP00000426970
Ensembl peptide - ENSP00000390102
Ensembl peptide - ENSP00000407818
NCBI entrez gene - 64854     See in Manteia.
OMIM - 612849
RefSeq - XM_017008557
RefSeq - NM_001134223
RefSeq - NM_001286767
RefSeq - NM_001286768
RefSeq - NM_022832
RefSeq Peptide - NP_001127695
RefSeq Peptide - NP_001273696
RefSeq Peptide - NP_001273697
RefSeq Peptide - NP_073743
swissprot - D6RIX7
swissprot - D6R9Z4
swissprot - P62068
swissprot - H7BZK6
Ensembl - ENSG00000109189
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp46ENSDARG00000045343Danio rerio
 USP46ENSGALG00000037496Gallus gallus
 Usp46ENSMUSG00000054814Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP12 / O75317 / ubiquitin specific peptidase 12ENSG0000015248489
USP35 / Q9P2H5 / ubiquitin specific peptidase 35ENSG0000011836933
USP38 / Q8NB14 / ubiquitin specific peptidase 38ENSG0000017018532


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007610 behavior IEA
 biological_processGO:0008343 adult feeding behavior IEA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic ISS
 biological_processGO:0048149 behavioral response to ethanol IEA
 biological_processGO:0060013 righting reflex IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0101005 ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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