Manteia - Molecule gene

ENSMUSG00000054814

Mus musculus

Features

Gene ID:	ENSMUSG00000054814

Biological name :	Usp46

Synonyms :	P62069 / ubiquitin specific peptidase 46 / Usp46

Possible biological names infered from orthology :	P62068

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	C3.3
Gene start:	73998453
Gene end:	74068431

Corresponding Affymetrix probe sets:	10530641 (MoGene1.0st) 1435325_at (Mouse Genome 430 2.0 Array) 1436518_at (Mouse Genome 430 2.0 Array) 1440416_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000070554 Ensembl peptide - ENSMUSP00000144284 Ensembl peptide - ENSMUSP00000114395 Ensembl peptide - ENSMUSP00000114060 NCBI entrez gene - 69727 See in Manteia. MGI - MGI:1916977 RefSeq - XM_006504269 RefSeq - NM_177561 RefSeq - XM_006504268 RefSeq Peptide - NP_808229 swissprot - D3YVU0 swissprot - P62069 swissprot - A0A0J9YUP8 swissprot - D3YVJ5 Ensembl - ENSMUSG00000054814

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
usp46	ENSDARG00000045343	Danio rerio
USP46	ENSGALG00000037496	Gallus gallus
USP46	ENSG00000109189	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Usp12 / Q9D9M2 / ubiquitin specific peptidase 12 / O75317*	ENSMUSG00000029640	89
Usp35 / ubiquitin specific peptidase 35 / Q9P2H5*	ENSMUSG00000035713	33
Usp38 / Q8BW70 / ubiquitin specific peptidase 38 / Q8NB14*	ENSMUSG00000038250	33

Protein motifs (from Interpro)

Interpro ID	Name
IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR018200	Ubiquitin specific protease, conserved site
IPR028889	Ubiquitin specific protease domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001662	behavioral fear response	IMP
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA
biological_process	GO:0007610	behavior	IEA
biological_process	GO:0008343	adult feeding behavior	IMP
biological_process	GO:0016579	protein deubiquitination	IEA
biological_process	GO:0032228	regulation of synaptic transmission, GABAergic	IMP
biological_process	GO:0048149	behavioral response to ethanol	IMP
biological_process	GO:0050862	positive regulation of T cell receptor signaling pathway	ISO
biological_process	GO:0060013	righting reflex	IMP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005829	cytosol	ISO
molecular_function	GO:0004843	thiol-dependent ubiquitin-specific protease activity	IEA
molecular_function	GO:0008233	peptidase activity	IEA
molecular_function	GO:0008234	cysteine-type peptidase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0101005	ubiquitinyl hydrolase activity	ISO

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001362	abnormal anxiety-related response	"altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]	Show Allelic Composition: Fgfr1^tm1Jpa/Fgfr1^tm1Jpa,Fgfr2^tm1Dor/Fgfr2^tm1Dor,Tg(Pax3-cre)1Joe/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0001447	abnormal nest building behavior	"deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Fgfr1^tm1Jpa/Fgfr1^tm1Jpa,Fgfr2^tm1Dor/Fgfr2^tm1Dor,Tg(Pax3-cre)1Joe/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0002863	improved righting response	"faster ability or less amount of time needed to recover from supine position" [J:86936]	Show Allelic Composition: Fgfr1^tm1Jpa/Fgfr1^tm1Jpa,Fgfr2^tm1Dor/Fgfr2^tm1Dor,Tg(Pax3-cre)1Joe/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0003360	depression-related behavior		Show Allelic Composition: Fgfr1^tm1Jpa/Fgfr1^tm1Jpa,Fgfr2^tm1Dor/Fgfr2^tm1Dor,Tg(Pax3-cre)1Joe/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Usp46^{Gt(pU17)1Imeg}/Usp46^{Gt(pU17)1Imeg} Genetic Background: B6.Cg-Usp46^{Gt(pU17)1Imeg}

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr