ENSMUSG00000029640


Mus musculus

Features
Gene ID: ENSMUSG00000029640
  
Biological name :Usp12
  
Synonyms : Q9D9M2 / ubiquitin specific peptidase 12 / Usp12
  
Possible biological names infered from orthology : O75317
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G3
Gene start: 146734809
Gene end: 146795006
  
Corresponding Affymetrix probe sets: 10535739 (MoGene1.0st)   1425805_a_at (Mouse Genome 430 2.0 Array)   1427478_at (Mouse Genome 430 2.0 Array)   1434483_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082754
NCBI entrez gene - 22217     See in Manteia.
MGI - MGI:1270128
RefSeq - NM_011669
RefSeq - XM_006504818
RefSeq Peptide - NP_035799
swissprot - Q9D9M2
Ensembl - ENSMUSG00000029640
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A4FUN7ENSDARG00000078109Danio rerio
 USP12ENSGALG00000034708Gallus gallus
 USP12ENSG00000152484Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp46 / P62069 / ubiquitin specific peptidase 46 / P62068*ENSMUSG0000005481488
Usp38 / Q8BW70 / ubiquitin specific peptidase 38 / Q8NB14*ENSMUSG0000003825032
Usp35 / ubiquitin specific peptidase 35 / Q9P2H5*ENSMUSG0000003571331


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination ISO
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0101005 ubiquitinyl hydrolase activity ISO


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcf7tm1a(EUCOMM)Wtsi/Tcf7tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tcf7tm1a(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046532 Ar / P19091 / Androgen receptor / P10275*  / complex
 ENSMUSG00000032512 Wdr48 / Q8BH57 / WD repeat domain 48 / Q8TAF3*  / complex






 

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