ENSMUSG00000038250


Mus musculus

Features
Gene ID: ENSMUSG00000038250
  
Biological name :Usp38
  
Synonyms : Q8BW70 / ubiquitin specific peptidase 38 / Usp38
  
Possible biological names infered from orthology : Q8NB14
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C2
Gene start: 80980733
Gene end: 81014928
  
Corresponding Affymetrix probe sets: 10579939 (MoGene1.0st)   1428592_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039943
NCBI entrez gene - 74841     See in Manteia.
MGI - MGI:1922091
RefSeq - NM_027554
RefSeq Peptide - NP_081830
swissprot - Q8BW70
Ensembl - ENSMUSG00000038250
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp38ENSDARG00000075798Danio rerio
 USP38ENSGALG00000009886Gallus gallus
 USP38ENSG00000170185Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp35 / ubiquitin specific peptidase 35 / Q9P2H5*ENSMUSG0000003571343
Usp12 / Q9D9M2 / ubiquitin specific peptidase 12 / O75317*ENSMUSG0000002964011
Usp46 / P62069 / ubiquitin specific peptidase 46 / P62068*ENSMUSG0000005481411


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR011989  Armadillo-like helical
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR033840  Ubiquitin-specific peptidase 38


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination ISO
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Usp22tm1b(KOMP)Wtsi/Usp22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Usp22tm1b(KOMP)Wtsi/Wtsi

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Usp22tm1b(KOMP)Wtsi/Usp22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Usp22tm1b(KOMP)Wtsi/Wtsi

 MP:0003795 abnormal bone structure 
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Allelic Composition: Usp22tm1b(KOMP)Wtsi/Usp22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Usp22tm1b(KOMP)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Usp22tm1b(KOMP)Wtsi/Usp22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Usp22tm1b(KOMP)Wtsi/Wtsi

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Usp22tm1b(KOMP)Wtsi/Usp22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Usp22tm1b(KOMP)Wtsi/Wtsi

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Usp22tm1b(KOMP)Wtsi/Usp22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Usp22tm1b(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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