ENSG00000110768


Homo sapiens

Features
Gene ID: ENSG00000110768
  
Biological name :GTF2H1
  
Synonyms : general transcription factor IIH subunit 1 / GTF2H1 / P32780
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.1
Gene start: 18322295
Gene end: 18367044
  
Corresponding Affymetrix probe sets: 202451_at (Human Genome U133 Plus 2.0 Array)   202453_s_at (Human Genome U133 Plus 2.0 Array)   242656_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431481
Ensembl peptide - ENSP00000433133
Ensembl peptide - ENSP00000439774
Ensembl peptide - ENSP00000436575
Ensembl peptide - ENSP00000435375
Ensembl peptide - ENSP00000265963
Ensembl peptide - ENSP00000393638
NCBI entrez gene - 2965     See in Manteia.
OMIM - 189972
RefSeq - XM_006718208
RefSeq - NM_001142307
RefSeq - NM_005316
RefSeq Peptide - NP_001135779
RefSeq Peptide - NP_005307
swissprot - E9PM51
swissprot - F5H0Y9
swissprot - E9PI26
swissprot - E9PL58
swissprot - P32780
Ensembl - ENSG00000110768
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gtf2h1ENSDARG00000026701Danio rerio
 GTF2H1ENSGALG00000042340Gallus gallus
 Gtf2h1ENSMUSG00000006599Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005607  BSD domain
 IPR011993  PH-like domain superfamily
 IPR013876  TFIIH p62 subunit, N-terminal
 IPR027079  TFIIH subunit Tfb1/GTF2H1
 IPR035925  BSD domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006293 nucleotide-excision repair, preincision complex stabilization TAS
 biological_processGO:0006294 nucleotide-excision repair, preincision complex assembly TAS
 biological_processGO:0006295 nucleotide-excision repair, DNA incision, 3"-to lesion TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006360 transcription by RNA polymerase I IBA
 biological_processGO:0006361 transcription initiation from RNA polymerase I promoter TAS
 biological_processGO:0006362 transcription elongation from RNA polymerase I promoter TAS
 biological_processGO:0006363 termination of RNA polymerase I transcription TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006370 7-methylguanosine mRNA capping TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0070816 phosphorylation of RNA polymerase II C-terminal domain IBA
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 cellular_componentGO:0000439 core TFIIH complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005675 holo TFIIH complex IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008094 DNA-dependent ATPase activity IDA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IDA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase I Chain Elongation
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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