ENSG00000111331


Homo sapiens

Features
Gene ID: ENSG00000111331
  
Biological name :OAS3
  
Synonyms : 2-5-oligoadenylate synthetase 3 / OAS3 / Q9Y6K5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.13
Gene start: 112938352
Gene end: 112973249
  
Corresponding Affymetrix probe sets: 218400_at (Human Genome U133 Plus 2.0 Array)   232666_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000228928
Ensembl peptide - ENSP00000447323
Ensembl peptide - ENSP00000448388
Ensembl peptide - ENSP00000449299
NCBI entrez gene - 4940     See in Manteia.
OMIM - 603351
RefSeq - XM_017019363
RefSeq - NM_006187
RefSeq - XM_005253889
RefSeq Peptide - NP_006178
swissprot - F8VS35
swissprot - Q9Y6K5
swissprot - F8VWK9
swissprot - H0YHL3
Ensembl - ENSG00000111331
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Oas3ENSMUSG00000032661Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OAS2 / P29728 / 2-5-oligoadenylate synthetase 2ENSG0000011133531
OAS1 / P00973 / 2-5-oligoadenylate synthetase 1ENSG0000008912719
OASL / Q15646 / 2-5-oligoadenylate synthetase likeENSG0000013511412


Protein motifs (from Interpro)
Interpro ID Name
 IPR002934  Polymerase, nucleotidyl transferase domain
 IPR006116  2-5-oligoadenylate synthetase, N-terminal
 IPR006117  2-5-oligoadenylate synthetase, conserved site
 IPR018952  2"-5"-oligoadenylate synthetase 1, domain 2/C-terminal
 IPR026774  2"-5"-oligoadenylate synthase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006139 nucleobase-containing compound metabolic process TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060337 type I interferon signaling pathway TAS
 biological_processGO:0060700 regulation of ribonuclease activity IDA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001730 2"-5"-oligoadenylate synthetase activity IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interferon gamma signaling
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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