ENSG00000135114


Homo sapiens

Features
Gene ID: ENSG00000135114
  
Biological name :OASL
  
Synonyms : 2-5-oligoadenylate synthetase like / OASL / Q15646
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.31
Gene start: 121019111
Gene end: 121039242
  
Corresponding Affymetrix probe sets: 205660_at (Human Genome U133 Plus 2.0 Array)   210797_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000257570
Ensembl peptide - ENSP00000341125
Ensembl peptide - ENSP00000444127
Ensembl peptide - ENSP00000479512
NCBI entrez gene - 8638     See in Manteia.
OMIM - 603281
RefSeq - XM_017020141
RefSeq - NM_001261825
RefSeq - NM_003733
RefSeq - NM_198213
RefSeq - XM_017020140
RefSeq Peptide - NP_003724
RefSeq Peptide - NP_937856
RefSeq Peptide - NP_001248754
swissprot - Q15646
swissprot - H0YGP3
Ensembl - ENSG00000135114
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OASLENSGALG00000013723Gallus gallus
 Oasl1ENSMUSG00000041827Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OAS1 / P00973 / 2-5-oligoadenylate synthetase 1ENSG0000008912729
OAS3 / Q9Y6K5 / 2-5-oligoadenylate synthetase 3ENSG0000011133126
OAS2 / P29728 / 2-5-oligoadenylate synthetase 2ENSG0000011133525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR006116  2-5-oligoadenylate synthetase, N-terminal
 IPR006117  2-5-oligoadenylate synthetase, conserved site
 IPR018952  2"-5"-oligoadenylate synthetase 1, domain 2/C-terminal
 IPR026774  2"-5"-oligoadenylate synthase
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060337 type I interferon signaling pathway TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046966 thyroid hormone receptor binding TAS


Pathways (from Reactome)
Pathway description
Interferon gamma signaling
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / reaction / complex






 

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