ENSG00000111335


Homo sapiens

Features
Gene ID: ENSG00000111335
  
Biological name :OAS2
  
Synonyms : 2-5-oligoadenylate synthetase 2 / OAS2 / P29728
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.13
Gene start: 112978395
Gene end: 113011723
  
Corresponding Affymetrix probe sets: 204972_at (Human Genome U133 Plus 2.0 Array)   206553_at (Human Genome U133 Plus 2.0 Array)   228607_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450307
Ensembl peptide - ENSP00000342278
Ensembl peptide - ENSP00000446977
Ensembl peptide - ENSP00000483679
Ensembl peptide - ENSP00000376362
Ensembl peptide - ENSP00000411763
NCBI entrez gene - 4939     See in Manteia.
OMIM - 603350
RefSeq - NM_016817
RefSeq - NM_001032731
RefSeq - NM_002535
RefSeq Peptide - NP_001027903
RefSeq Peptide - NP_058197
RefSeq Peptide - NP_002526
swissprot - P29728
swissprot - A0A087X0V5
swissprot - F8VPI5
swissprot - F8W1C5
Ensembl - ENSG00000111335
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Oas2ENSMUSG00000032690Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OAS3 / Q9Y6K5 / 2-5-oligoadenylate synthetase 3ENSG0000011133146
OAS1 / P00973 / 2-5-oligoadenylate synthetase 1ENSG0000008912726
OASL / Q15646 / 2-5-oligoadenylate synthetase likeENSG0000013511418


Protein motifs (from Interpro)
Interpro ID Name
 IPR002934  Polymerase, nucleotidyl transferase domain
 IPR006116  2-5-oligoadenylate synthetase, N-terminal
 IPR006117  2-5-oligoadenylate synthetase, conserved site
 IPR018952  2"-5"-oligoadenylate synthetase 1, domain 2/C-terminal
 IPR026774  2"-5"-oligoadenylate synthase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006139 nucleobase-containing compound metabolic process TAS
 biological_processGO:0006401 RNA catabolic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0009615 response to virus TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060337 type I interferon signaling pathway ISS
 biological_processGO:1903487 regulation of lactation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001730 2"-5"-oligoadenylate synthetase activity IMP
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interferon gamma signaling
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111335 OAS2 / P29728 / 2-5-oligoadenylate synthetase 2  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr