ENSG00000089127


Homo sapiens

Features
Gene ID: ENSG00000089127
  
Biological name :OAS1
  
Synonyms : 2-5-oligoadenylate synthetase 1 / OAS1 / P00973
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.13
Gene start: 112906777
Gene end: 112933222
  
Corresponding Affymetrix probe sets: 202869_at (Human Genome U133 Plus 2.0 Array)   205552_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474083
Ensembl peptide - ENSP00000450286
Ensembl peptide - ENSP00000475139
Ensembl peptide - ENSP00000202917
Ensembl peptide - ENSP00000388001
Ensembl peptide - ENSP00000415721
Ensembl peptide - ENSP00000448001
Ensembl peptide - ENSP00000448348
Ensembl peptide - ENSP00000448790
Ensembl peptide - ENSP00000449053
NCBI entrez gene - 4938     See in Manteia.
OMIM - 164350
RefSeq - XM_017019362
RefSeq - NM_001032409
RefSeq - NM_001320151
RefSeq - NM_002534
RefSeq - NM_016816
RefSeq - XM_006719434
RefSeq - XM_011538413
RefSeq - XM_017019361
RefSeq Peptide - NP_001027581
RefSeq Peptide - NP_001307080
RefSeq Peptide - NP_058132
RefSeq Peptide - NP_002525
swissprot - F8VXY3
swissprot - H0YI20
swissprot - H0YIB8
swissprot - S4R3A5
swissprot - P00973
swissprot - C6EMZ7
swissprot - F8VPW7
swissprot - F8VUC8
Ensembl - ENSG00000089127
  
Related genetic diseases (OMIM): 222100 - {Diabetes mellitus, type 1, susceptibility to}, 222100
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Oas1aENSMUSG00000052776Mus musculus
 Oas1bENSMUSG00000029605Mus musculus
 Oas1cENSMUSG00000001166Mus musculus
 Oas1dENSMUSG00000032623Mus musculus
 Oas1eENSMUSG00000066867Mus musculus
 Oas1fENSMUSG00000053765Mus musculus
 Oas1gENSMUSG00000066861Mus musculus
 Oas1hENSMUSG00000001168Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OAS3 / Q9Y6K5 / 2-5-oligoadenylate synthetase 3ENSG0000011133150
OAS2 / P29728 / 2-5-oligoadenylate synthetase 2ENSG0000011133546
OASL / Q15646 / 2-5-oligoadenylate synthetase likeENSG0000013511436


Protein motifs (from Interpro)
Interpro ID Name
 IPR002934  Polymerase, nucleotidyl transferase domain
 IPR006116  2-5-oligoadenylate synthetase, N-terminal
 IPR006117  2-5-oligoadenylate synthetase, conserved site
 IPR018952  2"-5"-oligoadenylate synthetase 1, domain 2/C-terminal
 IPR026774  2"-5"-oligoadenylate synthase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0060337 type I interferon signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001730 2"-5"-oligoadenylate synthetase activity IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interferon gamma signaling
Interferon alpha/beta signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000089127 OAS1 / P00973 / 2-5-oligoadenylate synthetase 1  / complex / reaction






 

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