ENSG00000111885


Homo sapiens

Features
Gene ID: ENSG00000111885
  
Biological name :MAN1A1
  
Synonyms : MAN1A1 / mannosidase alpha class 1A member 1 / P33908
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q22.31
Gene start: 119177209
Gene end: 119349761
  
Corresponding Affymetrix probe sets: 208116_s_at (Human Genome U133 Plus 2.0 Array)   221760_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357453
NCBI entrez gene - 4121     See in Manteia.
OMIM - 604344
RefSeq - XM_011535833
RefSeq - NM_005907
RefSeq - XM_005266986
RefSeq Peptide - NP_005898
swissprot - P33908
Ensembl - ENSG00000111885
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 man1a1ENSDARG00000005652Danio rerio
 MAN1A1ENSGALG00000014878Gallus gallus
 Man1aENSMUSG00000003746Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAN1A2 / O60476 / mannosidase alpha class 1A member 2ENSG0000019816261
MAN1C1 / Q9NR34 / mannosidase alpha class 1C member 1ENSG0000011764351
MAN1B1 / Q9UKM7 / mannosidase alpha class 1B member 1ENSG0000017723930


Protein motifs (from Interpro)
Interpro ID Name
 IPR001382  Glycoside hydrolase family 47
 IPR036026  Seven-hairpin glycosidases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006491 N-glycan processing IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:1904381 Golgi apparatus mannose trimming TAS
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity TAS
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0015923 mannosidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA


Pathways (from Reactome)
Pathway description
Intra-Golgi traffic
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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