ENSG00000117643


Homo sapiens

Features
Gene ID: ENSG00000117643
  
Biological name :MAN1C1
  
Synonyms : MAN1C1 / mannosidase alpha class 1C member 1 / Q9NR34
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.11
Gene start: 25617468
Gene end: 25786207
  
Corresponding Affymetrix probe sets: 214180_at (Human Genome U133 Plus 2.0 Array)   218918_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263979
Ensembl peptide - ENSP00000482317
Ensembl peptide - ENSP00000363452
Ensembl peptide - ENSP00000363449
NCBI entrez gene - 57134     See in Manteia.
OMIM - 616772
RefSeq - XM_017001860
RefSeq - NM_001289010
RefSeq - NM_020379
RefSeq Peptide - NP_001275939
RefSeq Peptide - NP_065112
swissprot - Q9NR34
swissprot - B1AJZ5
swissprot - A0A087WZ31
swissprot - A6NGN6
Ensembl - ENSG00000117643
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAN1C1ENSDARG00000067912Danio rerio
 MAN1C1ENSGALG00000001038Gallus gallus
 Man1c1ENSMUSG00000037306Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAN1A1 / P33908 / mannosidase alpha class 1A member 1ENSG0000011188553
MAN1A2 / O60476 / mannosidase alpha class 1A member 2ENSG0000019816252
MAN1B1 / Q9UKM7 / mannosidase alpha class 1B member 1ENSG0000017723930


Protein motifs (from Interpro)
Interpro ID Name
 IPR001382  Glycoside hydrolase family 47
 IPR036026  Seven-hairpin glycosidases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006487 protein N-linked glycosylation TAS
 biological_processGO:0006491 N-glycan processing IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:1904381 Golgi apparatus mannose trimming TAS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030173 integral component of Golgi membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Intra-Golgi traffic
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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