ENSG00000198162


Homo sapiens

Features
Gene ID: ENSG00000198162
  
Biological name :MAN1A2
  
Synonyms : MAN1A2 / mannosidase alpha class 1A member 2 / O60476
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p12
Gene start: 117367449
Gene end: 117528872
  
Corresponding Affymetrix probe sets: 1552481_s_at (Human Genome U133 Plus 2.0 Array)   214242_at (Human Genome U133 Plus 2.0 Array)   217282_at (Human Genome U133 Plus 2.0 Array)   217920_at (Human Genome U133 Plus 2.0 Array)   217921_at (Human Genome U133 Plus 2.0 Array)   217922_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000348959
Ensembl peptide - ENSP00000396362
Ensembl peptide - ENSP00000402416
Ensembl peptide - ENSP00000412706
NCBI entrez gene - 10905     See in Manteia.
OMIM - 604345
RefSeq - XM_011540536
RefSeq - NM_006699
RefSeq - XM_006710302
RefSeq Peptide - NP_006690
swissprot - O60476
swissprot - Q5T9E3
swissprot - H0Y7H1
swissprot - H0Y543
Ensembl - ENSG00000198162
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 man1a2ENSDARG00000041728Danio rerio
 ENSGALG00000041564Gallus gallus
 ENSGALG00000014361Gallus gallus
 Man1a2ENSMUSG00000008763Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAN1A1 / P33908 / mannosidase alpha class 1A member 1ENSG0000011188562
MAN1C1 / Q9NR34 / mannosidase alpha class 1C member 1ENSG0000011764351
MAN1B1 / Q9UKM7 / mannosidase alpha class 1B member 1ENSG0000017723931


Protein motifs (from Interpro)
Interpro ID Name
 IPR001382  Glycoside hydrolase family 47
 IPR036026  Seven-hairpin glycosidases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006491 N-glycan processing TAS
 biological_processGO:0007585 respiratory gaseous exchange IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009100 glycoprotein metabolic process IEA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:1904381 Golgi apparatus mannose trimming TAS
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Intra-Golgi traffic
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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